Mitotic arrest induced in human DU145 prostate cancer cells in response to KHC-4 treatment

中山醫學大學機構典藏 CSMUIR > 醫學院 > 醫學系 > 期刊論文 > Item 310902500/17904

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Title:	Mitotic arrest induced in human DU145 prostate cancer cells in response to KHC-4 treatment
Authors:	Shen, Cheng-Huang Lin, Tien-Huang Hsieh, You-Liang Shen, Chia-Yao Kuo, Sheng-Chu Wu, Hsi-Chin Chien, Wen-Shin Hsieh, Dennis Jine-Yuan Wen, Su-Ying Ting, Wei-Jen Yao, Chun-Hsu Huang, Chih-Yang
Contributors:	中山醫大
Keywords:	KHC-4;DU145 cells;antiproliferation;cell cycle arrest;cell migration;inhibition
Date:	2015
Issue Date:	2017-06-30T09:40:59Z (UTC)
ISSN:	1520-4081
Abstract:	Abstract In this study, the antitumor activity of KHC-4 was analyzed using human prostate cancer (CaP) cells and the underlining anticancer mechanisms of KHC-4 were identified. KHC-4 inhibited cell proliferation and induced cytotoxicity in the castration-resistant CaP DU145 cell line. The most effective concentration of KHC-4 was 0.1 μM. Cell cycle analysis demonstrated that KHC-4 treatment caused G2/M arrest and a subsequent increase in the sub-G1 population. Furthermore, KHC-4 is up-regulated p21, p27, and p53 in a time- and concentration-dependent manner. The exposure of cells to KHC-4 induced Cdk1/cyclin B1 complex activity, which led to cell cycle arrest. Moreover, KHC-4 inhibited the activities of MMP-2 and MMP-9 to inhibit tumor cell metastasis. © 2015 Wiley Periodicals, Inc. Environ Toxicol 31: 1879–1887, 2016.
URI:	http://dx.doi.org/10.1002/tox.22189 https://ir.csmu.edu.tw:8080/ir/handle/310902500/17904
Relation:	Environ Toxicol. 2015 Aug 25.
Appears in Collections:	[醫學系] 期刊論文

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