Heat Killed Lactobacillus reuteri GMNL-263 Reduces Fibrosis Effects on the Liver and Heart in High Fat Diet-Hamsters via TGF-β Suppression

doi:10.3390/ijms161025881

中山醫學大學機構典藏 CSMUIR > 醫學院 > 醫學系 > 期刊論文 > Item 310902500/17898

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题名:	Heat Killed Lactobacillus reuteri GMNL-263 Reduces Fibrosis Effects on the Liver and Heart in High Fat Diet-Hamsters via TGF-β Suppression
作者:	Ting, Wei-Jen Kuo, Wei-Wen Hsieh, Dennis Jine-Yuan Yu-Lan Yeh, 4,5 Cecilia-Hsuan Day Chen, Ya-Hui Chen, Ray-Jade Padma, Viswanadha Vijaya Chen, Yi-Hsing Huang, Chih-Yang
贡献者:	中山醫大
关键词:	Lactobacillus reuteri GMNL-263;cardiovascular diseases;transforming growth factor β
日期:	2015
上传时间:	2017-06-30T09:18:23Z (UTC)
出版者:	Int J Mol Sci
ISSN:	http://dx.doi.org/10.3390/ijms161025881 1661-6596
摘要:	Abstract Obesity is one of the major risk factors for nonalcoholic fatty liver disease (NAFLD), and NAFLD is highly associated with an increased risk of cardiovascular disease (CVD). Scholars have suggested that certain probiotics may significantly impact cardiovascular health, particularly certain Lactobacillus species, such as Lactobacillus reuteri GMNL-263 (Lr263) probiotics, which have been shown to reduce obesity and arteriosclerosis in vivo. In the present study, we examined the potential of heat-killed bacteria to attenuate high fat diet (HFD)-induced hepatic and cardiac damages and the possible underlying mechanism of the positive effects of heat-killed Lr263 oral supplements. Heat-killed Lr263 treatments (625 and 3125 mg/kg-hamster/day) were provided as a daily supplement by oral gavage to HFD-fed hamsters for eight weeks. The results show that heat-killed Lr263 treatments reduce fatty liver syndrome. Moreover, heat-killed Lactobacillus reuteri GMNL-263 supplementation in HFD hamsters also reduced fibrosis in the liver and heart by reducing transforming growth factor β (TGF-β) expression levels. In conclusion, heat-killed Lr263 can reduce lipid metabolic stress in HFD hamsters and decrease the risk of fatty liver and cardiovascular disease.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/17898
關聯:	Int J Mol Sci. 2015 Oct 28;16(10):25881-96.
显示于类别:	[醫學系] 期刊論文

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