Impairment of tumor-initiating stem-like property and reversal of epithelial–mesenchymal transdifferentiation in head and neck cancer by resveratrol treatment

doi:10.1002/mnfr.201200150

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 牙醫學系暨碩士班 > 期刊論文 > Item 310902500/17867

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/17867

Title:	Impairment of tumor-initiating stem-like property and reversal of epithelial–mesenchymal transdifferentiation in head and neck cancer by resveratrol treatment
Authors:	Hu, Fang-Wei Tsai, Lo-Lin Yu, Chuan-Hang Chen, Pei-Ni Chou, Ming-Yung Yu, Cheng-Chia
Contributors:	中山醫學大學
Date:	2012
Issue Date:	2017-06-29T08:41:10Z (UTC)
ISSN:	1613-4125
Abstract:	Abstract Scope Recent reports have demonstrated that head and neck cancer-derived tumor-initiating cells (HNC-TICs) presented high tumorigenic, chemoradioresistant, metastatic properties, and were coupled with gain of epithelial–mesenchymal transition (EMT) characteristics. The aim of this study was to investigate the chemotherapeutic effect and regulatory mechanisms of resveratrol on HNC-TICs. Methods and results We first observed that the treatment of resveratrol significantly downregulated the ALDH1 activity and CD44 positivity of head and neck cancer (HNC) cells in a dose-dependent manner (p < 0.05). Moreover, resveratrol treatment reduced self-renewal property and stemness genes signatures (Oct4, Nanog, and Nestin) expression in sphere-forming HNC-TICs. Additionally, the repressive effect of resveratrol on in vitro malignant properties including invasiveness/anchorage-independent growth was mediated by regulating productions of EMT markers Slug, ZEB1, N-cadherin, E-cadherin, and Vimentin. Importantly, an in vivo nude mice model showed that resveratrol treatment to xenograft tumors by oral gavage reduced tumor growth, stemness, and EMT markers in vivo. Lastly, synergistic effect of resveratrol and conventional chemotreatment attenuated tumor-initiating cells property in HNC-TICs. Conclusions Our results demonstrated that resveratrol would be a valuable therapeutics clinically in combination with conventional chemotherapy treatment modalities for malignant HNCs by elimination of tumor-initiating stem-like and EMT properties.
URI:	http://dx.doi.org/10.1002/mnfr.201200150 https://ir.csmu.edu.tw:8080/ir/handle/310902500/17867
Relation:	Molecular Nutrition & Food Research Previous article in issue: The intestinal bioavailability of vaccenic acid and activation of peroxisome proliferator-activated receptor-α and -γ in a rodent model of dyslipidemia and the metabolic syndrome Next article in issue: MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach View issue TOC Volume 56, Issue 8 August 2012 Pages 1247–1258
Appears in Collections:	[牙醫學系暨碩士班] 期刊論文

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	334	View/Open

View Licence

Loading...