中山醫學大學機構典藏 CSMUIR:Item 310902500/17805
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    题名: Multidrug Resistance 1 Gene Variants, Pesticide Exposure, and Increased Risk of DNA Damage
    作者: Chen, Chun-Chieh
    Huang, Chun-Huang
    Wu, Man-Tzu Marcie
    Chou, Chia-Hsuan
    Huang, Chia-Chen
    Tseng, Tzu-Yen
    Chang, Fang-Yu
    Li, Ying-Ti
    Tsai, Chun-Cheng
    Wang, Tsung-Shing
    Wong, Ruey-Hong
    贡献者: 醫學研究所
    日期: 2014-03-26
    上传时间: 2017-06-27T07:12:35Z (UTC)
    出版者: Biomed Res Int
    ISSN: 2314-6133
    摘要: Abstract
    The P-glycoprotein, encoded by the multidrug resistance (MDR)1 gene, extrudes fat-soluble compounds to the extracellular environment. However, the DNA damage of pesticides in subjects with genetic variation in MDR1 has not been investigated. In this study, the comet assay was applied to examine the extent of DNA damage in the peripheral blood of 195 fruit growers who had been exposed to pesticides and 141 unexposed controls. The MDR1 polymorphisms were identified. Questionnaires were administered to obtain demographic data and occupational history. Results showed subjects experiencing high (2.14 μm/cell, P < 0.01) or low pesticide exposure (2.18 μm/cell, P < 0.01) had a significantly greater DNA tail moment than controls (1.28 μm/cell). Compared to the MDR1 T-129C (rs3213619) TC/CC carriers, the TT carriers had increased DNA tail moment in controls (1.30 versus 1.12 μm/cell, P < 0.01). Similar results were observed in the high and low pesticide-exposed groups. Combined analysis revealed that pesticide-exposed fruit growers with MDR1 -129 TT genotype had the greatest DNA damage in the subjects with the combinations of pesticide exposure and MDR1 -129 genotypes. In conclusion, pesticide exposed individuals with susceptible MDR1 -129 genotypes may experience increased risk of DNA damage.
    URI: https://www.doi.org/10.1155/2014/965729
    https://ir.csmu.edu.tw:8080/ir/handle/310902500/17805
    關聯: Biomed Res Int. 2014; 2014: 965729.
    显示于类别:[醫學系] 期刊論文

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