Multidrug Resistance 1 Gene Variants, Pesticide Exposure, and Increased Risk of DNA Damage

doi:10.1155/2014/965729

中山醫學大學機構典藏 CSMUIR > 醫學院 > 醫學系 > 期刊論文 > Item 310902500/17805

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/17805

Title:	Multidrug Resistance 1 Gene Variants, Pesticide Exposure, and Increased Risk of DNA Damage
Authors:	Chen, Chun-Chieh Huang, Chun-Huang Wu, Man-Tzu Marcie Chou, Chia-Hsuan Huang, Chia-Chen Tseng, Tzu-Yen Chang, Fang-Yu Li, Ying-Ti Tsai, Chun-Cheng Wang, Tsung-Shing Wong, Ruey-Hong
Contributors:	醫學研究所
Date:	2014-03-26
Issue Date:	2017-06-27T07:12:35Z (UTC)
Publisher:	Biomed Res Int
ISSN:	2314-6133
Abstract:	Abstract The P-glycoprotein, encoded by the multidrug resistance (MDR)1 gene, extrudes fat-soluble compounds to the extracellular environment. However, the DNA damage of pesticides in subjects with genetic variation in MDR1 has not been investigated. In this study, the comet assay was applied to examine the extent of DNA damage in the peripheral blood of 195 fruit growers who had been exposed to pesticides and 141 unexposed controls. The MDR1 polymorphisms were identified. Questionnaires were administered to obtain demographic data and occupational history. Results showed subjects experiencing high (2.14 μm/cell, P < 0.01) or low pesticide exposure (2.18 μm/cell, P < 0.01) had a significantly greater DNA tail moment than controls (1.28 μm/cell). Compared to the MDR1 T-129C (rs3213619) TC/CC carriers, the TT carriers had increased DNA tail moment in controls (1.30 versus 1.12 μm/cell, P < 0.01). Similar results were observed in the high and low pesticide-exposed groups. Combined analysis revealed that pesticide-exposed fruit growers with MDR1 -129 TT genotype had the greatest DNA damage in the subjects with the combinations of pesticide exposure and MDR1 -129 genotypes. In conclusion, pesticide exposed individuals with susceptible MDR1 -129 genotypes may experience increased risk of DNA damage.
URI:	https://www.doi.org/10.1155/2014/965729 https://ir.csmu.edu.tw:8080/ir/handle/310902500/17805
Relation:	Biomed Res Int. 2014; 2014: 965729.
Appears in Collections:	[醫學系] 期刊論文

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