Significant elevation of plasma cathepsin B and cystatin C in patients with community-acquired pneumonia.

doi:10.1016/j.cca.2011.12.010

中山醫學大學機構典藏 CSMUIR > 醫學院 > 醫學系 > 期刊論文 > Item 310902500/17727

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/17727

Title:	Significant elevation of plasma cathepsin B and cystatin C in patients with community-acquired pneumonia.
Authors:	YT, Lee SC, Chen LY, Shyu MC, Lee TC, Wu SM, Tsao SF, Yang
Contributors:	醫學研究所
Date:	2012
Issue Date:	2017-06-01T07:21:44Z (UTC)
ISSN:	0009-8981
Abstract:	BACKGROUND: We identified the relationship between plasma level changes of cathepsin B and cystatin C before and after antibiotic treatment in hospitalized adult patients with community-acquired pneumonia (CAP). METHODS: We collected blood specimens from 61 adult patients with CAP before and after antibiotic treatment and from 60 healthy controls and measured the plasma concentrations of cathepsin B and cystatin C expression using the enzyme-linked immunosorbent assay (ELISA). The APACHE II, CURB-65, and Pneumonia Severity Index (PSI) scores were determined to assess CAP severity in patients upon initial hospitalization. RESULTS: The results showed a decline in the number of WBCs and neutrophils, with decreases in the concentrations of CRP, cathepsin B, cystatin C, and the cathepsin B/cystatin C ratio being observed after antibiotic treatment. The plasma concentration of cathepsin B correlated with severity of CAP with the PSI score (r=0.290, p=0.025) and the CURB-65 score (r=0.258, p=0.047), respectively. The plasma concentration of cystatin C correlated with the APACHE II score (r=0.523, p<0.001), severity of CAP in the PSI score (r=0.721, p<0.001) and the CURB-65 score (r=0.609, p<0.001), respectively. CONCLUSIONS: Cathepsin B and cystatin C may play a role in the diagnosis and clinical assessment of the severity of CAP, which could potentially guide the development of treatment strategies.
URI:	http://dx.doi.org/10.1016/j.cca.2011.12.010 https://ir.csmu.edu.tw:8080/ir/handle/310902500/17727
Relation:	Clin Chim Acta. 2012 Mar 22;413(5-6):630-5.
Appears in Collections:	[醫學系] 期刊論文

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