This study examines changes in and the relationship among religiosity, spiritual well-being, and depressive symptoms in primarily Buddhist or Daoist Taiwanese adolescents. A total of 2,239 16- to 18-year-old adolescents from 4 high schools were randomly selected and completed a questionnaire at baseline and at 6-month follow-up. Half of the Taiwanese adolescents reported being religious (50%), with Buddhism or Daoism predominating in terms of religious affiliation. Around 80% of adolescents believed in a God, but less than 40% believed that religion is important. Mixed models found no significant relationships between religiosity and spirituality or between religiosity and depressive symptoms. Self-efficacy and life scheme are valid domains for the spirituality construct, and a reciprocal relationship was found between spiritual well-being and depressive symptoms. This reciprocal relationship in adolescents is discussed in terms of a Buddhist or Daoist cultural context.