Physical and biological effects of gellan gum on decreasing postoperative adhesion in a rat model

doi:10.1177/0883911513475942

中山醫學大學機構典藏 CSMUIR > 醫學科技學院 > 醫學檢驗暨生物技術學系暨碩士班 > 期刊論文 > Item 310902500/15944

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题名:	Physical and biological effects of gellan gum on decreasing postoperative adhesion in a rat model
作者:	Chang, Shwu-Jen Kuo, Shyh-Ming You, Jhen-Lin Wu, Ya-Rong Chen, Shu-Ying Lee, Ming-Wei
贡献者:	中山醫學大學
关键词:	Gellan;gum antiadhesion;ceruloplasmin;antiadhesion membranes type V collagen;extracellular matrix protein gene expression;tissue adhesion
日期:	2013
上传时间:	2016-09-06T07:27:14Z (UTC)
ISSN:	0883-9115
摘要:	An antiadhesion membrane made from gellan gum was fabricated and characterized. A 12-µm-thick membrane of gellan gum was prepared and reacted with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide to obtain a cross-linked membrane (G/A70) with 87% gel content and a tensile strength of 46.5 MPa. In vivo, the G/A70 membrane had 90% less tissue adhesion. Inflammation-related and extracellular matrix protein gene expression in a rat model of abdominal surgery was found by real-time quantitative reverse transcription polymerase chain reaction analysis. On day 3, after surgery, the gene expression of ceruloplasmin and type V collagen in the G/A70-treated group was 1.9 and 0.3 times that of the control group, respectively. The G/A70 membrane elicited mild inflammation but suppressed type V collagen synthesis and reduced the occurrence of tissue adhesion. These findings provide insights into the properties of gellan gum antiadhesion membranes and help to overcome problems involving tissue adhesions in surgical procedures.
URI:	http://dx.doi.org/10.1177/0883911513475942 https://ir.csmu.edu.tw:8080/ir/handle/310902500/15944
關聯:	Journal of Bioactive and Compatible Polymers March 2013 vol. 28 no. 2 178-187
显示于类别:	[醫學檢驗暨生物技術學系暨碩士班] 期刊論文

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