Synthesis and Characterization of Cinnamated Polygalacturonic Acid for Biomedical Application

中山醫學大學機構典藏 CSMUIR > 醫學科技學院 > 醫學檢驗暨生物技術學系暨碩士班 > 期刊論文 > Item 310902500/15942

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题名:	Synthesis and Characterization of Cinnamated Polygalacturonic Acid for Biomedical Application
作者:	Chang, Shih-Hsien;Wang, Kai-Sung;LeongZ, Weng-In;Lee, Ming-Wei
贡献者:	中山醫學大學
关键词:	polygalacturonic acid;cinmamate;photocrosslink;anti-adhesion
日期:	2013
上传时间:	2016-09-06T07:18:55Z (UTC)
摘要:	Polygalacturonic acid (PGA) with varying degrees of cinnamated subsititution were synthesized. 6.2- 15.1 % of the D-galacturonic residues of the cinnamated PGA (PGA-Cin) reacted with cinnamate groups. An investigation of the photochemical properties revealed that the photoconversion rate and rate constant of PGA-Cin was 80% and 5.95x 1O-3 s- 1 after UV irradiation. The anti-adhesion films prepared from PGA-Cin exhibited high gel content and were found to efficacious in inhibiting bacterial growth. We evaluated their biocompatibility and anti-adhesion capability in both in vitro and in vivo experiments. The PGA-Cin films did not show any evidence of cytotoxic effects, as they did not induce any significant increase of cytoplasmic LDH release from the L929 cells in contact with them. When implanted into rats, the PGA-Cin films (anti-adhesion incidence 80.9%) exhibited more anti-adhesion potential than the commercial product Sepra:fìlrn™ (anti-adhesion incidence 47.6%).
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/15942
關聯:	Chung Shan Medical Journa12013; 24:1-12
显示于类别:	[醫學檢驗暨生物技術學系暨碩士班] 期刊論文

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