Effect of RYR, MFA and MFB on serum lipids and antioxidant activity in rats

doi:10.1016/j.clnme.2012.06.003

中山醫學大學機構典藏 CSMUIR > 健康管理學院 > 健康餐飲暨產業管理學系暨碩士班 > 期刊論文 > Item 310902500/15843

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/15843

Title:	Effect of RYR, MFA and MFB on serum lipids and antioxidant activity in rats
Authors:	Yeh, Yen-Hung Hsieh, You-Liang Lee, Ya-Ting
Contributors:	中山醫學大學
Keywords:	Red yeast rice;Monascus metabolites;HMG-CoA reductase;ACAT;Fecal sterols;Antioxidant enzymes
Date:	2012
Issue Date:	2016-08-16T04:13:08Z (UTC)
ISSN:	2212-8263
Abstract:	Background & aims This study was designed to test the lipid-lowering and antioxidative activities of red yeast rice (RYR), in comparison to its components monasfluore A (MFA) and monasfluore B (MFB) in cholesterol-fed rats. Methods The control group only received cholesterol supplemented diet, whereas the other three groups received the same diet added with 1% RYR, or 1% MFA, or 1% MFB. Results All treatments (RYR, MFA and MFB) reduced the atherogenic index. Simply, MFA and MFB are statistically but slightly more effective than RYR (55–58% reduction versus 46% reduction). The MFA and MFB significantly lowered the atherogenic index compared to the RYR and control (P < 0.05). The hepatic HMG-CoA reductase activity was significantly lower in the MFA group than in the RYR and MFB groups (P < 0.05), while the hepatic ACAT activity was significantly decreased by all treatments with respect to the high cholesterol fed group (P < 0.05). The overall potential of the antioxidant system was significantly enhanced by the RYR, MFA and MFB supplements as the plasma and hepatic TBARS levels were lowered while the hepatic superoxide dismutase activity and glutathione levels were increased by the treatments in comparison with the high cholesterol fed rats (P < 0.05). Conclusions Collectively, these results suggest that the supplementation of RYR, MFA and MFB increased antioxidant activity in rats. Furthermore, we observed that all treatments promoted the excretion of neutral and acidic sterols (P < 0.05), that could contribute to explain lower plasma and, hepatic cholesterol levels found in treated animal.
URI:	http://dx.doi.org/10.1016/j.clnme.2012.06.003 https://ir.csmu.edu.tw:8080/ir/handle/310902500/15843
Relation:	e-SPEN Journal Volume 7, Issue 5, October 2012, Pages e176–e181
Appears in Collections:	[健康餐飲暨產業管理學系暨碩士班] 期刊論文

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