Impact of uPA system gene polymorphisms on the susceptibility of environmental factors to carcinogenesis and the development of clinicopathology of oral cancer.

doi:10.1245/s10434-010-1432-2

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 牙醫學系暨碩士班 > 期刊論文 > Item 310902500/15774

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题名:	Impact of uPA system gene polymorphisms on the susceptibility of environmental factors to carcinogenesis and the development of clinicopathology of oral cancer.
作者:	CJ, Weng CW, Lin TT, Chung CM, Tsai MK, Chen SF, Yang
贡献者:	中山醫大口腔科學研究所
日期:	2010-12-02
上传时间:	2016-08-11T07:29:25Z (UTC)
ISSN:	1068-9265
摘要:	BACKGROUND: The levels of urokinase plasminogen activator (uPA) system in tumor tissues are implicated as prognostic biomarkers in a wide range of malignancies. However, their possible impact on the risk and prognosis of oral cancer and the susceptibility of environmental carcinogens to oral cancer remains poorly investigated. METHODS: The genetic polymorphisms of uPA, uPA receptor (uPAR), and plasminogen activator inhibitor (PAI)-1 were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 253 patients with oral cancer and 344 healthy controls. RESULTS: There was no significant effect of uPA system genes on the susceptibility of oral cancer; however, the impact of uPA system gene polymorphisms on the susceptibility of betel nut and tobacco consumptions to oral cancer was revealed, except for that of uPAR gene polymorphism on tobacco consumption. Patients with oral cancer with at least one 5G allele of PAI-1 gene have a low risk for the development of clinical stage III or IV (p ≤ 0.05) and lymph node metastasis (p ≤ 0.05) compared with those with 4G/4G homozygotes. CONCLUSIONS: Our results suggest that the combination of uPA system gene polymorphisms and environmental carcinogens was related to the risk of oral cancer, and the genetic polymorphism of PAI-1 was associated with a low risk to the clinicopathological development of oral cancer.
URI:	http://dx.doi.org/10.1245/s10434-010-1432-2 https://ir.csmu.edu.tw:8080/ir/handle/310902500/15774
關聯:	Ann Surg Oncol. 2011 Mar;18(3):805-12
显示于类别:	[牙醫學系暨碩士班] 期刊論文

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