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https://ir.csmu.edu.tw:8080/ir/handle/310902500/15773
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| Title: | Metallothionein-1 genotypes in the risk of oral squamous cell carcinoma |
| Authors: | AI, Zavras;AJ, Yoon;MK, Chen;CW, Lin;SF, Yang |
| Contributors: | 中山醫大口腔科學研究所 |
| Date: | 2010-12-03 |
| Issue Date: | 2016-08-11T07:27:40Z (UTC)
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| ISSN: | 1068-9265 |
| Abstract: | BACKGROUND:
We conducted an independent analysis of metallothionein 1 (MT-1) rs8052394, rs11076161, rs8052334, rs964372, rs7191779, and rs708274 in 587 individuals who were either healthy controls or subjects with oral squamous cell carcinoma (OSCC).
METHODS:
All participants provided a nucleic acid sample (blood) as well as epidemiologic information on covariates or "risk factors" for OSCC, including tobacco, alcohol, and areca quid use. The genotyping result was used in a logistic regression model that examined main effects as well as statistical interactions while controlling for confounders.
RESULTS:
MT-1 is involved in regulation of zinc and copper homeostasis. It also is a potent antioxidant and its polymorphisms correlate with the risk for OSCC. Rs11076161 A, rs964372 C, and rs7191779 C alleles were protective against OSCC (adjusted OR = 0.53, 0.49, 0.36, respectively; p < 0.05), whereas rs8052394 A alleles were associated with increased risk. Areca quid chewing and tobacco use were strong risk factors for developing the disease and were associated with 20- and 8-fold increases in adjusted risk (p < 0.05), respectively.
CONCLUSIONS:
Controlling for the effects of age, gender, areca quid, tobacco, and alcohol use, individuals with inherited the MT-1 rs11076161 AA, rs964372 CC, and rs7191779 GC genotypes may experience significant protection against OSCC, whereas individuals carrying the MT-1 rs8052394 A allele seem exposed to higher risk. |
| URI: | http://dx.doi.org/10.1245/s10434-010-1431-3
https://ir.csmu.edu.tw:8080/ir/handle/310902500/15773 |
| Relation: | Ann Surg Oncol. 2011 May;18(5):1478-83 |
| Appears in Collections: | [牙醫學系暨碩士班] 期刊論文
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