Role of ERCC5 polymorphism in risk of hepatocellular carcinoma.

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 牙醫學系暨碩士班 > 期刊論文 > Item 310902500/15769

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题名:	Role of ERCC5 polymorphism in risk of hepatocellular carcinoma.
作者:	AJ, Yoon WH, Kuo CW, Lin SF, Yang
贡献者:	中山醫大口腔科學研究所
日期:	2011-06-11
上传时间:	2016-08-11T07:17:38Z (UTC)
ISSN:	1792-1074
摘要:	Excision repair cross‑complementing rodent repair deficiency, complementation group 5 (ERCC5, XPG) is a key molecule in DNA damage repair. We analyzed the contribution of ERCC5 rs751402 polymorphism in increased susceptibility to hepatocellular carcinoma (HCC). A total of 96 patients diagnosed with HCC and 336 healthy controls provided blood samples for analysis of rs751402 genotypes. Demographic data and information on habitual use of tobacco and alcohol were collected. After adjusting for covariates, rs751402 homozygocity for allele C was found to confer a statistically significant protection [adjusted odds ratio (AOR)=0.56; 95% CI, 0.35‑0.89; p=0.01] against HCC, whereas rs751402 T alleles were associated with increased risk (AOR=1.69; 95% CI, 0.74‑3.87). Individuals with the inherited ERCC rs751402 CC genotype may experience significant protection against HCC, whereas individuals with T alleles appear to be exposed to higher risk.
URI:	http://dx.doi.org/10.3892/ol.2011.325 https://ir.csmu.edu.tw:8080/ir/handle/310902500/15769
關聯:	Oncol Lett. 2011 Sep 1;2(5):911-914.
显示于类别:	[牙醫學系暨碩士班] 期刊論文

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