Impact of VEGF-C gene polymorphisms and environmental factors on oral cancer susceptibility in Taiwan

doi:10.1371/journal.pone.0060283

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 牙醫學系暨碩士班 > 期刊論文 > Item 310902500/15756

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/15756

Title:	Impact of VEGF-C gene polymorphisms and environmental factors on oral cancer susceptibility in Taiwan
Authors:	MH, Chien YF, Liu CH, Hsin CH, Lin CH, Shih SF, Yang CW, Cheng CW, Lin
Contributors:	中山醫大口腔科學研究所
Date:	2013-04-04
Issue Date:	2016-08-11T06:37:11Z (UTC)
ISSN:	1932-6203
Abstract:	BACKGROUND: Oral cancer, which is the fourth most common male cancer, is associated with environmental carcinogens in Taiwan. Vascular endothelial growth factor (VEGF)-C, an angiogenic/lymphangiogenic factor with high expression levels in tumor tissues, plays important roles in the development of several malignancies. This study was designed to examine associations of five VEGF-C gene polymorphisms with the susceptibility to and clinicopathological characteristics of oral squamous cell carcinoma. METHODOLOGY/PRINCIPAL FINDINGS: Five single-nucleotide polymorphisms (SNPs) of VEGF-C were analyzed by a real-time polymerase chain reaction (PCR) in 470 male patients with oral cancer and 426 cancer-free controls. In this study, we found that the VEGF-C rs7664413 and rs2046463 polymorphisms were associated with oral-cancer susceptibility but not with any clinicopathological parameters. The GGACA or GACTG haplotype of five VEGF-C SNPs (rs3775194, rs11947611, rs1485766, rs7664413, and rs2046463) combined was also related to the risk of oral cancer. Among 611 male smokers, VEGF-C polymorphism carriers who also chewed betel quid were found to have a 14.5-24.2-fold risk of having oral cancer compared to the VEGF-C wild-type carrier who did not chew betel quid. Among 461 male betel-quid chewers, VEGF-C polymorphism carriers who also smoked had a 2.7-18.1-fold risk of having oral cancer compared to those who carried the wild type but did not smoke. CONCLUSIONS: Our results suggest that the two SNPs of VEGF-C (rs7664413 and rs2046463) and either of two haplotypes of five SNPs combined have potential predictive significance in oral carcinogenesis. Gene-environmental interactions among VEGF-C polymorphisms, smoking, and betel-quid chewing might alter one's susceptibility to oral cancer.
URI:	http://dx.doi.org/10.1371/journal.pone.0060283 https://ir.csmu.edu.tw:8080/ir/handle/310902500/15756
Relation:	PLoS One. 2013 Apr 4;8(4):e60283
Appears in Collections:	[牙醫學系暨碩士班] 期刊論文

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