Kaempferol reduces matrix metalloproteinase-2 expression by down-regulating ERK1/2 and the activator protein-1 signaling pathways in oral cancer cells.

doi:10.1371/journal.pone.0080883

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 牙醫學系暨碩士班 > 期刊論文 > Item 310902500/15752

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题名:	Kaempferol reduces matrix metalloproteinase-2 expression by down-regulating ERK1/2 and the activator protein-1 signaling pathways in oral cancer cells.
作者:	CW, Lin PN, Chen MK, Chen WE, Yang CH, Tang SF, Yang YS, Hsieh
贡献者:	中山醫大口腔科學研究所
日期:	2013-11-20
上传时间:	2016-08-11T06:25:13Z (UTC)
ISSN:	1932-6203
摘要:	BACKGROUND: Kaempferol has been proposed as a potential drug for cancer chemoprevention and treatment because it is a natural polyphenol contained in plant-based foods. Recent studies have demonstrated that kaempferol protects against cardiovascular disease and cancer. Based on this finding, we investigated the mechanisms by which kaempferol produces the anti-metastatic effect in human tongue squamous cell carcinoma SCC4 cells. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we provided molecular evidence associated with the anti-metastatic effect of kaempferol by demonstrating a substantial suppression of SCC4 cell migration and invasion. This effect was associated with reduced expressions of MMP-2 and TIMP-2 mRNA and protein levels. Analysis of the transcriptional regulation indicated that kaempferol inhibited MMP-2 transcription by suppressing c-Jun activity. Kaempferol also produced an inhibitory effect on the phosphorylation of ERK1/2. CONCLUSIONS: These findings provide new insights into the molecular mechanisms involved in the anti-metastatic effect of kaempferol, and are valuable in the prevention of oral cancer metastasis.
URI:	http://dx.doi.org/10.1371/journal.pone.0080883 https://ir.csmu.edu.tw:8080/ir/handle/310902500/15752
關聯:	PLoS One. 2013 Nov 20;8(11):e80883
显示于类别:	[牙醫學系暨碩士班] 期刊論文

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