teractions between environmental factors and melatonin receptor type 1A polymorphism in relation to oral cancer susceptibility and clinicopathologic development.

doi:10.1371/journal.pone.0121677

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 牙醫學系暨碩士班 > 期刊論文 > Item 310902500/15743

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题名:	teractions between environmental factors and melatonin receptor type 1A polymorphism in relation to oral cancer susceptibility and clinicopathologic development.
作者:	FY, Lin CW, Lin SF, Yang WJ, Lee YW, Lin LM, Lee JL, Chang WC, Weng CH, Lin MH, Chien
贡献者:	中山醫大口腔科學研究所
日期:	2015-03-25
上传时间:	2016-08-11T04:25:02Z (UTC)
ISSN:	1932-6203
摘要:	BACKGROUND: The purpose of this study was to explore the combined effect of melatonin receptor type 1A (MTNR1A) gene polymorphisms and exposure to environmental carcinogens on the susceptibility and clinicopathological characteristics of oral cancer. METHODOLOGY AND PRINCIPAL FINDINGS: Three polymorphisms of the MTNR1A gene from 618 patients with oral cancer and 560 non-cancer controls were analyzed by real-time polymerase chain reaction (PCR). The CTA haplotype of the studied MTNR1A polymorphisms (rs2119882, rs13140012, rs6553010) was related to a higher risk of oral cancer. Moreover, MTNR1A gene polymorphisms exhibited synergistic effects of environmental factors (betel quid and tobacco use) on the susceptibility of oral cancer. Finally, oral-cancer patients with betel quid-chewing habit who had T/T allele of MTNR1A rs13140012 were at higher risk for developing an advanced clinical stage and lymph node metastasis. CONCLUSION: These results support gene-environment interactions of MTNR1A polymorphisms with smoking and betel quid-chewing habits possibly altering oral-cancer susceptibility and metastasis.
URI:	http://dx.doi.org/10.1371/journal.pone.0121677 https://ir.csmu.edu.tw:8080/ir/handle/310902500/15743
關聯:	PLoS One. 2015 Mar 25;10(3):e0121677
显示于类别:	[牙醫學系暨碩士班] 期刊論文

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