Association of matrix metalloproteinase-11 polymorphisms with susceptibility and clinicopathologic characteristics for oral squamous cell carcinoma.

doi:10.1002/hed.23771

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 牙醫學系暨碩士班 > 期刊論文 > Item 310902500/15740

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.csmu.edu.tw:8080/ir/handle/310902500/15740

题名:	Association of matrix metalloproteinase-11 polymorphisms with susceptibility and clinicopathologic characteristics for oral squamous cell carcinoma.
作者:	CW, Lin SF, Yang CY, Chuang HP, Lin CH, Hsin
贡献者:	中山醫大口腔科學研究所
关键词:	genetic polymorphism;matrix metalloproteinase-11 (MMP-11);oral cancer
日期:	2014-07-19
上传时间:	2016-08-11T04:15:58Z (UTC)
ISSN:	1043-3074
摘要:	BACKGROUND: The purpose of this study was to investigate the influence of genetic polymorphisms of the matrix metalloproteinase-11 (MMP-11) gene on the susceptibility of oral squamous cell carcinoma (OSCC). METHODS: Four single-nucleotide polymorphisms (SNPs) of the MMP-11 gene from 595 patients with oral cancer and 561 noncancer controls were analyzed by real-time polymerase chain reaction (PCR). RESULTS: MMP-11 gene polymorphisms exhibit synergistic effects of environmental factors (betel nut chewing and tobacco use) on the susceptibility of OSCC. Furthermore, among patients with OSCC with betel nut consumption, those who have at least one polymorphic C allele of MMP-11 rs738792 have an increased incidence of lymph node metastasis when compared with those patients homozygous for T/T. CONCLUSION: Our results showed that the combined effects of the MMP-11 gene polymorphisms and environmental carcinogens are related to an increased risk for the development of OSCC and may be a predictive factor for tumor lymph node metastasis in Taiwanese with OSCC. © 2014 Wiley Periodicals, Inc.
URI:	http://dx.doi.org/10.1002/hed.23771 https://ir.csmu.edu.tw:8080/ir/handle/310902500/15740
關聯:	Head Neck. 2015 Oct;37(10):1425-31
显示于类别:	[牙醫學系暨碩士班] 期刊論文

文件中的档案:

档案	描述	大小	格式	浏览次数
index.html		0Kb	HTML	323	检视/开启

检视Licence

在CSMUIR中所有的数据项都受到原著作权保护.

TAIR相关文章

数据加载中.....