Combinations of FUT2 gene polymorphisms and environmental factors are associated with oral cancer risk.

doi:10.1007/s13277-015-4367-1

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 牙醫學系暨碩士班 > 期刊論文 > Item 310902500/15736

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题名:	Combinations of FUT2 gene polymorphisms and environmental factors are associated with oral cancer risk.
作者:	KJ, Su CC, Ho CW, Lin MK, Chen SC, Su YL, Yu SF, Yang
贡献者:	中山醫大口腔科學研究所
关键词:	Fucosyltransferase-2;Oral cancer;Single-nucleotide polymorphisms
日期:	2015-12-08
上传时间:	2016-08-11T04:06:05Z (UTC)
ISSN:	1010-4283
摘要:	In humans, fucosyltransferase-2 (FUT2) plays an important role in α1,2- linkage of fucose and participates in complex cellular processes such as fertilization, embryogenesis, and immune responses. However, little information is available concerning the FUT2 expression in tumorigenesis. The aim of this work was to investigate the combined effect of FUT2 gene polymorphisms and exposure to environmental carcinogens on the susceptibility and clinic pathological characteristics of oral cancer. Four SNPs of the FUT2 gene (rs281377, rs1047781, rs601338, and rs602662) from 1200 non-cancer controls and 700 oral squamous cell carcinoma (OSCC) patients were analyzed by real-time polymerase chain reaction (PCR). The samples were further analyzed to clarify the associations between these gene polymorphisms and the risk of OSCC, and the impact of these SNPs on the susceptibility and clinic pathological characteristics of OSCC. After adjusting for other covariant, we observed that betel quid chewing among 1255 smokers who carrying at least one C genotype (TC and CC) at rs281377 and least one T genotype (TA and TT) at rs1047781 were exhibited synergistic effects of environmental factors (betel quid and cigarette use) on the susceptibility of oral cancer. Taken together, our results support gene-environment interactions of FUT2 polymorphisms with smoking and betel quid chewing habits possibly altering oral cancer susceptibility. Furthermore, to our knowledge, this is the first study of association between FUT2 gene variants and OSCC risk.
URI:	http://dx.doi.org/10.1007/s13277-015-4367-1 https://ir.csmu.edu.tw:8080/ir/handle/310902500/15736
關聯:	Tumour Biol. 2016 May;37(5):6647-52
显示于类别:	[牙醫學系暨碩士班] 期刊論文

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