Osteogenesis and angiogenesis properties of dental pulp cell on novel injectable tricalcium phosphate cement by silica doped.

doi:10.1016/j.msec.2014.05.038

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 口腔醫學研究所 > 期刊論文 > Item 310902500/15661

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/15661

Title:	Osteogenesis and angiogenesis properties of dental pulp cell on novel injectable tricalcium phosphate cement by silica doped.
Authors:	Su, YF;Lin, CC;Huang, TH;Chou, MY;Yang, JJ;Shie, MY
Contributors:	中山醫學大學
Keywords:	Angiogenic;Biodegradable;Injectability;Osteogenic;Silica-doped;β-Tricalcium phosphate
Date:	2014-05-23
Issue Date:	2016-08-05T07:34:21Z (UTC)
Publisher:	Elsevier
ISSN:	0928-4931
Abstract:	β-Tricalcium phosphate (β-TCP) is an osteoconductive material in clinical. In this study, we have doped silica (Si) into β-TCP and enhanced its bioactive and osteostimulative properties. To check its effectiveness, a series of Si-doped with different ratios were prepared to make new bioactive and biodegradable biocomposites for bone repair. Formation of the diametral tensile strength, ions released and weight loss of cements was considered after immersion. In addition, we also examined the behavior of human dental pulp cells (hDPCs) cultured on Si-doped β-TCP cements. The results showed that setting time and injectability of the Si-doped β-TCP cements were decreased as the Si content was increased. At the end of the immersion point, weight losses of 30.1%, 36.9%, 48.1%, and 55.3% were observed for the cement doping 0%, 10%, 20%, and 30% Si into β-TCP cements, respectively. In vitro cell experiments show that the Si-rich cements promote human dental pulp cell (hDPC) proliferation and differentiation. However, when the Si-doped in the cement is more than 20%, the amount of cells and osteogenesis protein of hDPCs was stimulated by Si released from Si-doped β-TCP cements. The degradation of β-TCP and osteogenesis of Si gives a strong reason to believe that these Si-doped β-TCP cements may prove to be promising bone repair materials.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/15661 http://dx.doi.org/10.1016/j.msec.2014.05.038
Relation:	Mater Sci Eng C Mater Biol Appl. 2014 Sep;42:672-80.
Appears in Collections:	[口腔醫學研究所] 期刊論文

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