Effect of hemodialysis on the plasma level of type IV collagenases and their inhibitors.

doi:10.1016/S0009-9120(02)00331-4

中山醫學大學機構典藏 CSMUIR > 醫學科技學院 > 醫學檢驗暨生物技術學系暨碩士班 > 期刊論文 > Item 310902500/11906

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题名:	Effect of hemodialysis on the plasma level of type IV collagenases and their inhibitors.
作者:	Chou FP;Chu SC;Cheng MC;Yang SF;Cheung WN;Chiou HL;Hsieh YS
贡献者:	中山醫學大學
关键词:	Hemodialysis;MMP-2;MMP-9;TIMP-1;TIMP-2
日期:	2002-07
上传时间:	2015-08-03T09:18:49Z (UTC)
ISSN:	0009-9120
摘要:	OBJECTIVES: Increased cell expression of matrix metalloproteinase-9 (MMP-9) was associated with the development of atherosclerosis and osseoarticular tissue destruction in hemodialysis patients. In this study, the pre- and post-HD plasma concentrations of type IV collagenases and their inhibitors in HD patients were examined. DESIGN AND METHODS: Commercial ELISA kits and Zymography techniques were used to assay the parameters in 40 patients pre- and post-HD session. RESULTS: After the hemodialysis process, MMP-9, MMP-2 and TIMP-2 levels were 124 +/- 72, 706 +/- 242 and 248 +/- 90 ng/mL, significantly different from the pre-HD values (187 +/- 148, 759 +/- 304 and 43 +/- 14 ng/mL). TIMP-1 were not affected by HD. Female subjects and patients with chronic glomerulonephritis had higher TIMP-2 than their counterparts (p < 0.05). The effect of gender on MMP-2 levels was interacted with that of membrane types (p < 0.01). CONCLUSION: These results indicated that the hemodialysis process tends to decrease the overall activity of the peripheral plasma MMP system in HD patients.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/11906 http://dx.doi.org/10.1016/S0009-9120(02)00331-4
關聯:	Clin Biochem. 2002 Jul;35(5):383-8
显示于类别:	[醫學檢驗暨生物技術學系暨碩士班] 期刊論文

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