The aberrant expression of cytosolic carbonic anhydrase and its clinical significance in human non-small cell lung cancer.

中山醫學大學機構典藏 CSMUIR > 醫學科技學院 > 醫學檢驗暨生物技術學系暨碩士班 > 期刊論文 > Item 310902500/11904

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题名:	The aberrant expression of cytosolic carbonic anhydrase and its clinical significance in human non-small cell lung cancer.
作者:	Chiang WL;Chu SC;Yang SS;Li MC;Lai JC;Yang SF;Chiou HL;Hsieh YS
贡献者:	中山醫學大學
关键词:	Carbonic anhydrase I;Carbonic anhydrase II;Non-small cell lung cancer
日期:	2002-12
上传时间:	2015-08-03T09:05:32Z (UTC)
ISSN:	0304-3835
摘要:	This study was designed to elucidate the possible relationship between the expression of cytosolic carbonic anhydrase (CA) and non-small cell lung cancer (NSCLC). The activity and protein expression patterns of carbonic anhydrase I (CAI) and II (CAII) of 70 NSCLC patients were analyzed by CA activity analysis, immunoblotting and immunohistochemical staining. The results showed that the CA activity and protein expression were significantly decreased in both squamous cell carcinoma (SCC) and adenocarcinoma (AD) (P<0.001 and P<0.001). From our study, it was suggested that the reduction of CAI and CAII in both SCC and AD patients may promote tumor cell motility and contribute to tumor growth and metastasis.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/11904 http://dx.doi.org/10.1016/S0304-3835(02)00078-2
關聯:	Cancer Lett. 2002 Dec 15;188(1-2):199-205.
显示于类别:	[醫學檢驗暨生物技術學系暨碩士班] 期刊論文

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