中山醫學大學機構典藏 CSMUIR:Item 310902500/11894
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    题名: Relationship between matrix metalloproteinase-2 activity and cystatin C levels in patients with hepatic disease
    作者: Tzy-Yen Chena;Yih-Shou Hsieh;Chi-Chieh Yang;Chi-Ping Wang;Shun-Fa Yang;Yan-Wen Chenga;Hui-Ling Chiou
    贡献者: 中山醫學大學
    关键词: MMP-2;Cystatin C;Hepatic disease
    日期: 2005-07
    上传时间: 2015-08-03T08:04:04Z (UTC)
    ISSN: 0009-9120
    摘要: Objectives:

    A direct relationship between cystatin C levels and the severity of hepatic disease has been revealed in our previous study. This study was aimed to consider whether a correlation exists between matrix metalloproteinases (MMPs), which have been proven to be involved in liver cirrhosis, and cystatin C to reflect the severity of hepatic disease.

    Design and Methods:

    A total of 154 consecutive patients with various liver diseases were recruited to determine their serum levels of cystatin C, MMP-2 and-9, together with other hepatic parameters. These were compared with 40 normal controls.

    Results:

    Average levels of MMP-2 and cystatin C were significantly higher in patients while MMP-9 was significantly lower, as compared to controls. A linear regression analysis has revealed a direct relationship between cystatin C and MMP-2 (Y = 83.39 + 270.56X, R = 0.38, P < 0.001), as well as between MMP-2 and the severity of liver diseases.

    Conclusion:

    This is the first study to demonstrate a correlation between cystatin C and MMP-2, suggesting that there may be certain interactions between cystatin C and MMP-2 in patients with hepatic diseases.
    URI: https://ir.csmu.edu.tw:8080/ir/handle/310902500/11894
    http://dx.doi.org/10.1016/j.clinbiochem.2005.03.005
    關聯: Clinical Biochemistry Volume 38, Issue 7, July 2005, 632–638
    显示于类别:[醫學檢驗暨生物技術學系暨碩士班] 期刊論文

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