Roles of central catecholamine and hypothalamic neuropeptide Y genome in the development of tolerance to phenylpropanolamine-mediated appetite suppression.

doi:10.1037/0735-7044.121.5.933

中山醫學大學機構典藏 CSMUIR > 醫學科技學院 > 醫學檢驗暨生物技術學系暨碩士班 > 期刊論文 > Item 310902500/11889

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题名:	Roles of central catecholamine and hypothalamic neuropeptide Y genome in the development of tolerance to phenylpropanolamine-mediated appetite suppression.
作者:	Hsieh YS;Yang SF;Chiou HL;Kuo DY
贡献者:	中山醫學大學
日期:	2007-10
上传时间:	2015-07-31T10:45:19Z (UTC)
ISSN:	0735-7044
摘要:	Phenylpropanolamine (PPA) is an appetite suppressant. Repeated treatment with PPA can decrease food intake on initial days, but on subsequent days, food intake gradually returns to normal (tolerant effect). In an attempt to investigate the underlying mechanisms of PPA tolerance, the authors examined the roles of catecholamine (CAT) and hypothalamic neuropeptide Y (NPY) genome. Results revealed that pretreatment with either bupropion, a CAT transporter inhibitor, or a-methylparatyrosine, a tyrosine hydroxylase inhibitor, modulated the effect of PPA tolerance. Moreover, results also revealed that the alteration in NPY messenger RNA level coincided with the change of feeding behavior during PPA treatment and that infusions of NPY antisense oligonucleotide into the cerebroventricle abolished the effect of PPA tolerance. These findings suggest that cerebral CAT and hypothalamic NPY genome are involved in the development of tolerance to PPA-induced appetite suppression.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/11889 http://dx.doi.org/10.1037/0735-7044.121.5.933
關聯:	Behav Neurosci. 2007 Oct;121(5):933-40.
显示于类别:	[醫學檢驗暨生物技術學系暨碩士班] 期刊論文

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