中山醫學大學機構典藏 CSMUIR:Item 310902500/11819
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    题名: MicroRNA gene polymorphisms and environmental factors increase patient susceptibility to hepatocellular carcinoma.
    作者: Chu YH;Hsieh MJ;Chiou HL;Liou YS;Yang CC;Yang SF;Kuo WH
    贡献者: 中山醫學大學
    关键词: Multidrug resistance;P-Glycoprotein;ABCB1;Psoralen;Docetaxel;Lung cancer
    日期: 2014-02
    上传时间: 2015-07-30T04:23:16Z (UTC)
    ISSN: 0944-7113
    摘要: Micro RNAs (miRNAs) are small RNA fragments that naturally exist in the human body. Through various physiological mechanisms, miRNAs can generate different functions for regulating RNA protein levels and balancing abnormalities. Abnormal miRNA expression has been reported to be highly related to several diseases and cancers. Single-nucleotide polymorphisms (SNPs) in miRNAs have been reported to increase patient susceptibility and affect patient prognosis and survival. We adopted a case-control research design to verify the relationship between miRNAs and hepatocellular carcinoma.
    METHODOLOGY/PRINCIPAL FINDINGS:
    A total of 525 subjects, including 377 controls and 188 hepatocellular carcinoma patients, were selected. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and real-time PCR were used to analyze miRNA146a (rs2910164), miRNA149 (rs2292832), miRNA196 (rs11614913), and miRNA499 (rs3746444) genetic polymorphisms between the control group and the case group. The results indicate that people who carry the rs3746444 CT or CC genotypes may have a significantly increased susceptibility to hepatocellular carcinoma (adjusted odds ratio [AOR] = 2.84, 95% confidence interval [CI] = 1.88-4.30). In addition, when combined with environmental risk factors, such as smoking and alcohol consumption, interaction effects were observed between gene polymorphisms and environmental factors (odds ratio [OR] = 4.69, 95% CI = 2.52-8.70; AOR = 3.38, 95% CI = 1.68-6.80).
    CONCLUSIONS:
    These results suggest that a significant association exists between miRNA499 SNPs and hepatocellular carcinoma. Gene-environment interactions of miRNA499 polymorphisms, smoking, and alcohol consumption might alter hepatocellular carcinoma susceptibility.
    URI: https://ir.csmu.edu.tw:8080/ir/handle/310902500/11819
    http://dx.doi.org/10.1016/j.phymed.2014.03.008
    關聯: PLoS One. 2014 Feb 26;9(2):e89930
    显示于类别:[醫學檢驗暨生物技術學系暨碩士班] 期刊論文

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