Complementary Usage of Rhodiola crenulata (L.) in Chronic Obstructive Pulmonary Disease Patients: The Effects on Cytokines and T Cells

doi:10.1002/ptr.5259

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Title:	Complementary Usage of Rhodiola crenulata (L.) in Chronic Obstructive Pulmonary Disease Patients: The Effects on Cytokines and T Cells
Authors:	Chen, Shih-Pin Liu, Rosa Huang Lu, Tsong-Ming James, Cheng-Chung Wu, Tzu-Chin Wei Tsai, Wei-Yu Tsai, Chung-Hung Yang, Chi-Chiang
Contributors:	中山醫學大學
Keywords:	COPD;cytokine;Rhodiola;T cells
Date:	2015
Issue Date:	2015-07-29T08:12:45Z (UTC)
ISSN:	0951-418X
Abstract:	Although chronic obstructive pulmonary disease (COPD) is an inflammatory disease predominantly involving T cells, no study of Rhodiola as an immunomodulator in COPD patients has been reported. In this study, COPD patients took Rhodiola crenulata 500 mg (n = 38) or placebo (starch/phosphate buffered saline) (n = 19) daily for 12 weeks and were compared with untreated, age-matched, and sex-matched non-COPD control subjects. Our results showed that serum levels of IL-2, IL-10, and IFN-γ in COPD patients before treatment are significantly higher than levels in non-COPD controls (p < 0.05). A significant decrease in IFN-γ was seen in the Rhodiola treatment group (p < 0.05) but not in the placebo group (p > 0.05). The results suggested that Rhodiola treatment had beneficial antiinflammation effects, lower COPD assessment test score and decreased high-sensitivity C-reactive protein, on COPD patients (p < 0.05). The effects of Rhodiola treatment on COPD patients were shown to decrease the IFN-γ concentration and CD8+ count but increase the expressions of CD4+CD25+FOXP3+ and CD4+CD25+CD45+FOXP3+ in the blood significantly (p < 0.05). This is the first trial using Rhodiola as a complementary therapy for COPD patients. T cells play an important role in the pathogenesis of COPD through the increased expression of CD8+ T cells and IFN-γ and may be a viable target for potential therapy. Copyright © 2014 John Wiley & Sons, Ltd.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/11798 http://dx.doi.org/10.1002/ptr.5259
Relation:	Phytotherapy Research Volume 29, Issue 4, pages 518–525, April 2015
Appears in Collections:	[School of Medical Laboratory and Biotechnology] journal paper

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