Lipocalin 2, a new GADD153 target gene, as an apoptosis inducer of endoplasmic reticulum stress in lung cancer cells.

doi:10.1016/j.taap.2012.07.005

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Title:	Lipocalin 2, a new GADD153 target gene, as an apoptosis inducer of endoplasmic reticulum stress in lung cancer cells.
Authors:	Hsin, IL Hsiao, YC Wu, MF Jan, MS Tang, SC Lin, YW Hsu, CP Ko, JL
Contributors:	中山醫學大學
Keywords:	Apoptosis;ER stress;GADD153/CHOP;Lipocalin 2/NGAL;Thapsigargin;Unfolded protein response
Date:	2012
Issue Date:	2015-07-28T10:39:08Z (UTC)
ISSN:	0041-008X
Abstract:	Endoplasmic reticulum (ER) stress is activated under severe cellular conditions. GADD153, a member of the C/EBP family, is an unfolded protein response (UPR) responsive transcription factor. Increased levels of lipocalin 2, an acute phase protein, have been found in several epithelial cancers. The aim of this study is to investigate the function of lipocalin 2 in lung cancer cells under ER stress. Treatment with thapsigargin, an ER stress activator, led to increases in cytotoxicity, ER stress, apoptosis, and lipocalin 2 expression in A549 cells. GADD153 silencing decreased lipocalin 2 expression in A549 cells. On chromatin immunoprecipitation assay, ER stress increased GADD153 DNA binding to lipocalin 2 promoter. Furthermore, silencing of lipocalin 2 mitigated ER stress-mediated apoptosis in A549 cells. Our findings demonstrated that lipocalin 2 is a new GADD153 target gene that mediates ER stress-induced apoptosis. Copyright © 2012 Elsevier Inc. All rights reserved.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/11761 http://dx.doi.org/10.1016/j.taap.2012.07.005
Relation:	Toxicol Appl Pharmacol. 2012 Sep 15;263(3):330-7.
Appears in Collections:	[免疫學研究所] 期刊論文

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