Cystamine ameliorates ventricular hypertrophy associated with modulation of IL-6-mediated signaling in lupus-prone mice.

doi:10.1016/j.lfs.2013.01.027

中山醫學大學機構典藏 CSMUIR > 醫學院 > 免疫學研究所 > 期刊論文 > Item 310902500/11645

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/11645

Title:	Cystamine ameliorates ventricular hypertrophy associated with modulation of IL-6-mediated signaling in lupus-prone mice.
Authors:	Tzang, BS Hsu, TC Chen, TY Huang, CY Li, SL Kao, SH
Contributors:	中山醫學大學
Keywords:	Cystamine;Lupus-prone mice;Left ventricular hypertrophy;IL-6;MEK5
Date:	2013
Issue Date:	2015-07-27T08:13:47Z (UTC)
ISSN:	0024-3205
Abstract:	AIMS: The aim of this study is to investigate the protective effects of cystamine on lupus-associated cardiac hypertrophy. MAIN METHODS: Balb/c and lupus-prone NZB/W-F1 mice were individually randomized into sham group (saline, n=16) and cystamine group (n=16). Mice received saline or cystamine (100 mmol in 100 μL saline) by daily intraperitoneal injection for 2 consecutive weeks. Morphological, histological, and biochemical alterations were investigated. KEY FINDINGS: Cystamine decreased both left ventricular (LV) mass and LV mass/tissue-to-blood ratio (TBR) in NZB/W-F1 mice (p<0.05), whereas slight effects were observed in Balb/c mice. Moreover, cystamine reduced levels of atrial natriuretic peptide (ANP), C-reactive protein (CRP), heart type-fatty acid binding protein (h-FABP), creatine kinase-MB (CK-MB) and IL-6 in LV tissues of NZB/W-F1 mice (p<0.05). Additionally, in LV tissues of NZB/W-F1 mice, suppression of hypertrophic signaling mediated by IL-6 in response to administration of cystamine was revealed, including phosphorylation of MEK5, ERK5, c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38) (p<0.05). SIGNIFICANCE: Cystamine alleviated LV hypertrophy in NZB/W-F1 mice as a result of decrease in hypertrophic mediators and suppression of IL-6 mediated hypertrophic signaling. Copyright © 2013 Elsevier Inc. All rights reserved.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/11645 http://dx.doi.org/10.1016/j.lfs.2013.01.027
Relation:	Life Sci. 2013 Apr 9;92(12):719-26.
Appears in Collections:	[免疫學研究所] 期刊論文

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