中山醫學大學機構典藏 CSMUIR:Item 310902500/11596
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    题名: Evaluation of serum autoantibody levels in the diagnosis of ovarian endometrioma.
    作者: Yi, YC
    Wang, SC
    Chao, CC
    Su, CL
    Lee, YL
    Chen, LY
    贡献者: 中山醫學大學
    日期: 2010
    上传时间: 2015-07-23T09:38:02Z (UTC)
    ISSN: 0887-8013
    摘要: OBJECTIVE:
    We analyzed autoantibodies against tumor-associated antigens (TAAs) in the serum of patients with endometrioma and healthy controls to determine whether autoantibodies can be accurate biomarkers for the diagnosis of ovarian endometrioma.
    METHODS:
    Serum samples were obtained from 56 patients with endometriosis and 66 healthy women who served as normal controls. The titers of antibodies against a panel of eight TAAs were analyzed using enzyme-linked immunosorbent assay.
    RESULTS:
    We found that the serum IGFII mRNA-binding protein 1 (IMP1) autoantibody and cyclin B1 autoantibody could discriminate between healthy controls and endometriosis patients (AUC-ROC 0.777; 95% confidence interval [CI] 0.694-0.860, P<0.0005, and AUC-ROC 0.614; 95%confidence interval [CI] 0.513-0.714, P=0.031, respectively). Using 0.073 and 0.007 as the cutoff values for IMP1 and Cyclin B1 autoantibody, respectively, the sensitivity and specificity of IMP1 were 85.7 and 63.6%, respectively. When cylcin B1 was combined with IMP1, the specificity increased to 72.7% and the sensitivity slightly decreased to 83.9%.
    CONCLUSIONS:
    Our data suggest that IMP1 alone or combined with cyclin B1 seems to fulfill the requirements of sensitivity and specificity to become a useful clinical biomarker of endometrioma. However, further studies will be required to establish the predictive value and to support the clinical use of IMP1/cyclin B1 in the diagnosis and/or screening of endometriosis.
    J. Clin. Lab. Anal. 24:357-362, 2010. © 2010 Wiley-Liss, Inc.
    URI: https://ir.csmu.edu.tw:8080/ir/handle/310902500/11596
    http://dx.doi.org/10.1002/jcla.20415
    關聯: J Clin Lab Anal. 2010;24(5):357-62.
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