Activations of c-fos/c-jun signaling are involved in the modulation of hypothalamic superoxide dismutase (SOD) and neuropeptide Y (NPY) gene expression in amphetamine-mediated appetite suppression.

doi:10.1016/j.taap.2005.07.006

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Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/11510

Title:	Activations of c-fos/c-jun signaling are involved in the modulation of hypothalamic superoxide dismutase (SOD) and neuropeptide Y (NPY) gene expression in amphetamine-mediated appetite suppression.
Authors:	Hsieh, YS Yang, SF Chiou, HL Kuo, DY
Contributors:	中山醫學大學
Keywords:	Amphetamine;NPY;Immediate early gene;Superoxide dismutase;Feeding behavior
Date:	2006
Issue Date:	2015-07-21T10:41:16Z (UTC)
ISSN:	0041-008X
Abstract:	Amphetamine (AMPH) is known as an anorectic agent. The mechanism underlying the anorectic action of AMPH has been attributed to its inhibitory action on hypothalamic neuropeptide Y (NPY), an appetite stimulant in the brain. This study was aimed to examine the molecular mechanisms behind the anorectic effect of AMPH. Results showed that AMPH treatment decreased food intake, which was correlated with changes of NPY mRNA level, but increased c-fos, c-jun and superoxide dismutase (SOD) mRNA levels in hypothalamus. To determine if c-fos or c-jun was involved in the anorectic response of AMPH, infusions of antisense oligonucleotide into the brain were performed at 1 h before daily AMPH treatment in freely moving rats, and the results showed that c-fos or c-jun knockdown could block this anorectic response and restore NPY mRNA level. Moreover, c-fos or c-jun knockdown could partially block SOD mRNA level that might involve in the modulation of NPY gene expression. It was suggested that c-fos/c-jun signaling might involve in the central regulation of AMPH-mediated feeding suppression via the modulation of NPY gene expression.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/11510 http://dx.doi.org/10.1016/j.taap.2005.07.006
Relation:	Toxicol Appl Pharmacol. 2006 Apr 15;212(2):99-109.
Appears in Collections:	[The Institute of Biochemistry, Microbiology and Immunology ] Journal Paper

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