Antimetastatic activities of Selaginella tamariscina (Beauv.) on lung cancer cells in vitro and in vivo.

doi:10.1016/j.jep.2006.10.010

中山醫學大學機構典藏 CSMUIR > 醫學院 > 生化微生物免疫研究所 > 期刊論文 > Item 310902500/11497

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题名:	Antimetastatic activities of Selaginella tamariscina (Beauv.) on lung cancer cells in vitro and in vivo.
作者:	Yang, SF Chu, SC Liu, SJ Chen, YC Chang, YZ Hsieh, YS
贡献者:	中山醫學大學
关键词:	Selaginella tamariscina;Invasion;Motility;MMP-2;u-PA
日期:	2007
上传时间:	2015-07-21T09:59:29Z (UTC)
ISSN:	0378-8741
摘要:	Selaginella tamariscina is a traditional Chinese herb for the therapy of chronic trachitis and has been approved some anti-tumor activity. However, the anti-metastasis effects of Selaginella tamariscina in the lung cancer have not been understood clearly. The objectives of study were to investigate the effects of the Selaginella tamariscina extracts (STE) on the invasion and motility of highly metastatic A549 and Lewis lung carcinoma (LLC) cells. To further investigate the precise involvement of STE in tumor metastasis, A549 and LLC cells were treated with STE at various concentrations (0-100 microg/mL) for a specified period. The results from zymography showed that a STE treatment decreased (p<0.05) the expressions of matrix metalloproteinase (MMP)-2, -9 and urokinase plasminogen activator (u-PA) in a dose-dependent manner in the A549 and LLC cell. Meanwhile, their endogenous inhibitors, which are tissue inhibitor of metalloproteinase-2 (TIMP-2) and plasminogen activator inhibitor-1 (PAI-1), were increased in the A549 cell. Furthermore, the inhibitory effect of STE on the growth and metastasis of LLC cells in vivo was also proven. These results demonstrated that STE could be a candidate antimetastatic agent against lung cancer.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/11497 http://dx.doi.org/10.1016/j.jep.2006.10.010
關聯:	J Ethnopharmacol. 2007 Apr 4;110(3):483-9.
显示于类别:	[生化微生物免疫研究所] 期刊論文

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