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https://ir.csmu.edu.tw:8080/ir/handle/310902500/11437
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| 题名: | The Impact of IGF-I Gene Polymorphisms on Coronary Artery Disease Susceptibility |
| 作者: | Lin, Hsiu-Ling
Ueng, Kwo-Chang
Wang, Hsiang-Ling
Chen, Tsung-Po
Yang, Shun-Fa
Chu, Shu-Chen
Hsieh, Yih-Shou |
| 贡献者: | 中山醫學大學 |
| 关键词: | : IGF-I;IGFBP-3;single nucleotide polymorphism;coronary artery disease |
| 日期: | 2013 |
| 上传时间: | 2015-07-21T04:55:25Z (UTC)
|
| ISSN: | 0887-8013 |
| 摘要: | Background: Coronary artery disease
(CAD) was the second leading cause of
death for the past 3 years in Taiwan. The
insulin-like growth factor (IGF) system is
considered a new risk factor of CAD because
investigations show that the levels
and bioactivity of IGF-I and IGFBP-3
(where IGFBP is insulin-like growth factorbinding
protein) may be involved in elevating
the risk of CAD. This study investigated
the relationships among IGF-I +1770,
IGF-I +6093, and IGFBP-3 -202 genetic
polymorphisms and CAD in the Taiwanese
population. Methods: A total of 581 subjects,
including 390 non-CAD controls and
191 patients with CAD, were recruited and
the isolated DNA was subjected to realtime
polymerase chain to evaluate the effects
of these three polymorphic variants
on CAD. Results: Our results showed a
significant association between the IGF-I +1770 gene polymorphism and increased
risk of CAD. Furthermore, CAD patients
with a minimum of one mutant C allele,
T/C or C/C, in IGF-I +1770 gene polymorphism
had significantly high blood pressure
including systolic blood pressure (SBP; P =
0.025) and diastolic blood pressure (DBP;
P = 0.004), compared to CAD patients with
T/T homozygotes. Moreover, CAD patients
with a minimum of one mutant A allele,
G/A or A/A, in the IGF-I +6093 gene polymorphism
had a 1.695-fold elevated risk of
congestive heart failure (CHF), compared
to CAD patients with the G/G homozygote.
Conclusions: Polymorphism of IGF-I
+1770 was associated with increased CAD
risk. In CAD patients, the contributions of
IGF-I +1770 and +6093 could be through
the effect on blood pressure in CAD patients.
J. Clin. Lab. Anal. 27:162–169,
2013. C 2013 Wiley Periodicals, Inc. |
| URI: | https://ir.csmu.edu.tw:8080/ir/handle/310902500/11437
http://dx.doi.org/10.1002/jcla.21581 |
| 關聯: | Journal of Clinical Laboratory Analysis 27: 162–169 (2013) |
| 显示于类别: | [生化微生物免疫研究所] 期刊論文
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