中山醫學大學機構典藏 CSMUIR:Item 310902500/11433
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    题名: The neuropeptide Y Y1 receptor knockdown modulates activator protein 1-involved feeding behavior in amphetamine-treated rats
    作者: Hsieh, Yih-Shou
    Chen, Pei-Ni
    Yu, Ching-Han
    Liao, Jiuan-Miaw
    Kuo, Dong-Yih
    贡献者: 中山醫學大學
    关键词: NPY-Y1 receptor;c-Fos;c-Jun;AP-1;Appetite;Hypothalamus
    日期: 2013
    上传时间: 2015-07-21T04:40:53Z (UTC)
    摘要: Background
    Hypothalamic neuropeptide Y (NPY) and two immediate early genes, c-fos and c-jun, have been found to be involved in regulating the appetite-suppressing effect of amphetamine (AMPH). The present study investigated whether cerebral catecholamine (CA) might regulate NPY and POMC expression and whether NPY Y1 receptor (Y1R) participated in activator protein-1 (AP-1)–mediated feeding.

    Methods
    Rats were given AMPH daily for 4 days. Changes in the expression of NPY, Y1R, c-Fos, c-Jun, and AP-1 were assessed and compared.

    Results
    Decreased CA could modulate NPY and melanocortin receptor 4 (MC4R) expressions. NPY and food intake decreased the most on Day 2, but Y1R, c-Fos, and c-Jun increased by approximately 350%, 280%, and 300%, respectively, on Day 2. Similarly, AP-1/DNA binding activity was increased by about 180% on Day 2. The expression patterns in Y1R, c-Fos, c-Jun, and AP-1/DNA binding were opposite to those in NPY during AMPH treatment. Y1R knockdown was found to modulate the opposite regulation between NPY and AP-1, revealing an involvement of Y1R in regulating NPY/AP-1–mediated feeding.

    Conclusions
    These results point to a molecular mechanism of CA/NPY/Y1R/AP-1 signaling in the control of AMPH-mediated anorexia and may advance the medical research of anorectic and anti-obesity drugs.
    URI: https://ir.csmu.edu.tw:8080/ir/handle/310902500/11433
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