The upregulation of insulin-like growth factor-1 in oral submucous fibrosis

doi:10.1016/j.oraloncology.2005.05.006

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 牙醫學系暨碩士班 > 期刊論文 > Item 310902500/11340

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题名:	The upregulation of insulin-like growth factor-1 in oral submucous fibrosis
作者:	Tsai, Chung-Hung Yang, Shun-Fa Chen, Yi-Juai Chou, Ming-Yung Chang, Yu-Chao
贡献者:	中山醫學大學
关键词:	Arecoline;Buccal mucosal fibroblasts;Oral submucous fibrosis;Insulin-like growth factor-I
日期:	2005
上传时间:	2015-07-15T10:44:13Z (UTC)
ISSN:	1368-8375
摘要:	Insulin-like growth factor-1 (IGF-1) is a member of a family of two interacting polypeptide hormone ligands with close homology to proinsulin. IGF-1 can influence mesenchymal cell migration, proliferation, and extracellular matrix deposition, thus implicating it in the progression of fibrotic disorders. Currently, there is limited information about the regulation of IGF-1 expression in areca quid-associated oral submucous fibrosis (OSF). The aim of this study was to compare IGF-1 expression in normal human buccal mucosa and OSF specimens and further explore the potential mechanism that may lead to induce IGF-1 expression. Twenty OSF specimens and 10 normal buccal mucosa were examined by immunohistochemistry. The activity of IGF-1 from cells cultured from OSF and normal buccal mucosa were by using reverse-transcriptase polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA). Furthermore, the effect of arecoline, the major areca nut alkaloid, was added to explore the potential mechanism that may lead to induce IGF-1 expression. IGF-1 expression was significantly higher in OSF specimens (p < 0.05) and expressed mainly by fibroblasts, endothelial cells, and inflammatory cells. OSF demonstrated significantly higher IGF-1 protein expression than normal buccal mucosa fibroblast (BMF) both in mRNA and protein levels (p < 0.05). In addition, arecoline was also found to elevate IGF-1 mRNA and protein expression in a dose-dependent manner (p < 0.05). Taken together, the data presented here demonstrated that IGF-1 expression is significantly upregulated in OSF from areca quid chewers and arecoline may be responsible for the enhanced IGF-1 expression in vivo.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/11340 http://dx.doi.org/10.1016/j.oraloncology.2005.05.006
關聯:	Oral Oncology Volume 41, Issue 9, October 2005, Pages 940–946
显示于类别:	[牙醫學系暨碩士班] 期刊論文

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