Tissue Type Plasminogen Activator Level and Caseinolytic Activity in Clinically Healthy and Inflamed Human Dental Pulp

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 牙醫學系暨碩士班 > 期刊論文 > Item 310902500/11328

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題名:	Tissue Type Plasminogen Activator Level and Caseinolytic Activity in Clinically Healthy and Inflamed Human Dental Pulp
作者:	admin, admin
貢獻者:	中山醫學大學
關鍵詞:	pulp ； inflammation ； tissue type plasminogen activator ； caseinolytic activity
日期:	2007
上傳時間:	2015-07-15T10:16:20Z (UTC)
摘要:	The tissue-type plasminigen activator (t-PA) is one of the important proteolysis factors in the pathogenesis of pulpal inflammation. The purpose of this study was investigate t-PA levels in clinically healthy and inflamed human pulp tissue specimens. Thirty-one pulpal tissue specimens (9 clinically healthy and 22 inflamed pulps) were obtained from extracted third molars. The levels of t-PA between clinically healthy pulp and inflamed pulp tissues were compared using casein zymography and an enzyme-linked immunosorbent assay (ELISA). The Wilcoxon-Mann-Whitney rank sum test was applied for the statistical analysis of the results. The main casein secreted by human pulp tissues migrated at 70 kDa and represented t-PA. Secretion of the t-PA protein was found to be higher in inflamed pulp when compared with clinically healthy pulp tissues (P＜0.05). Similar results were also found by ELISA. Our findings demonstrated that t-PA levels and caseinolytic activities were significantly higher in inflamed pulp tissue compared with clinically healthy dental pulp. t-PA may play a key role in the breakdown of inflamed human dental pulp tissue.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/11328
關聯:	Journal of Dental Sciences ； 2 卷 3 期 (2007 / 09 / 01) ， P152 - 156
顯示於類別:	[牙醫學系暨碩士班] 期刊論文

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