Macrophage migration inhibitory factor induces ICAM-1and thrombomobulin expression in vitro.

中山醫學大學機構典藏 CSMUIR > 健康管理學院 > 營養學系暨碩士班 > 期刊論文 > Item 310902500/11234

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/11234

Title:	Macrophage migration inhibitory factor induces ICAM-1and thrombomobulin expression in vitro.
Authors:	Shyu, LY Yeh, TM Chang, HH Lin, DP Teng, YH Chen, LC Lee, HH
Contributors:	中山醫學大學
Date:	2012
Issue Date:	2015-07-14T07:54:02Z (UTC)
ISSN:	0049-3848
Abstract:	Macrophage migration inhibitory factor (MIF) is an important cytokine in the modulation of inflammatory and immune responses, but its role in coagulation remains to be elucidated. In this study, we investigated the potential role of MIF in coagulation through its influence on two factors, thrombomodulin (TM) and intercellular adhesion molecule-1 (ICAM-1). Recombinant human MIF was added to human microvascular endothelial cell line (HMEC-1) to investigate its influence on the expression of TM and ICAM-1. The results showed that both TM and ICAM-1 were induced with MIF addition in a dose-dependent and time-dependent manner. The expression of ICAM-1 and TM was increased as MIF doses were increased, with the highest expression seen at 12 hr after 400 ng/ml of MIF treatment. Besides, anti-MIF antibody treatment reduced the TM expression in HMEC-1 cells. In conclusion, our data support a role of MIF as an important factor in the regulation of coagulation. Copyright © 2011 Elsevier Ltd. All rights reserved.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/11234 http://dx.doi.org/10.1016/j.thromres.2011.08.011
Relation:	Thromb Res. 2012 Jan;129(1):43-9.
Appears in Collections:	[營養學系暨碩士班] 期刊論文

Files in This Item:

File	Description	Size	Format
index.html	期刊論文	0Kb	HTML	431	View/Open

View Licence