Prolactin Secretion and Intracellular Ca2+ Change in Rat Lactotroph Subpopulations Stimulated by Thyrotropin-Releasing Hormone

中山醫學大學機構典藏 CSMUIR > 醫學院 > 醫學系 > 期刊論文 > Item 310902500/11223

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题名:	Prolactin Secretion and Intracellular Ca2+ Change in Rat Lactotroph Subpopulations Stimulated by Thyrotropin-Releasing Hormone
作者:	Huang, Chih-Yang Kuo, Wei-Wen Tsai, Tsung-Po Wu, Der-Jinn Hsieh, Yih-Shou Paulus, S.Wang
贡献者:	中山醫學大學
关键词:	intracellular Ca2þ;lactotrophs prolactin;thyrotropin-releasing hormone
日期:	2002
上传时间:	2015-07-14T04:32:29Z (UTC)
摘要:	Thyrotropin-releasing hormone (TRH) may stimulate lactotrophs to increase intracellular Ca2þ and to secrete prolactin (PRL). In this study, PRL contents in lactotrophs were determined by the sequential cell immunoblot assay (SCIBA) and their changes in intracellular Ca2þwas analyzed by confocal microscopy. Significant correlations were found in the corresponding parameters between TRH treatments with a recovery interval of 2 h. Measuring the PRL contents after the first TRH treatment and then determining the intracellular Ca2þ changes after the second TRH treatment revealed four lactotroph subpopulations. Type I cells (51%) showed significant responses of both PRL secretion and intracellular Ca2þ concentration. Type II cells (22%) increased in PRL secretion, but without changes in intracellular Ca2þ. Type III cells (17%) have increased in intracellular Ca2þ, but without changes in PRL secretion. Type IV cells (10%) did not show changes in PRL secretion and intracellular Ca2þ. J. Cell. Biochem. 87: 126–132, 2002.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/11223
關聯:	Journal of Cellular Biochemistry 87:126–132 (2002)
显示于类别:	[醫學系] 期刊論文

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