Tumor-Promoting Effect of GGN-MRP Extract from the Maillard

doi:10.1021/jf0106897

中山醫學大學機構典藏 CSMUIR > 醫學院 > 生化微生物免疫研究所 > 期刊論文 > Item 310902500/10828

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题名:	Tumor-Promoting Effect of GGN-MRP Extract from the Maillard
作者:	Chen, Chang-Che Tseng, Tsui-Hwa Jeng-Dong, Hsu Wang, Chau-Jong
贡献者:	中山醫學大學
关键词:	GGN-MRP;B(a)P initiation;tumor promotion;neoplastic transformation
日期:	2001
上传时间:	2015-05-15T07:35:24Z (UTC)
ISSN:	0021-8561
摘要:	GGN-MRP is an extract from the Maillard reaction products of nitrite with glucose and glycine in the Maillard browning system. No genotoxicity of GGN-MRP in culture hepatocyte was found. A two-stage transformation protocol was used to transform chemically mouse embryo fibroblast C3H10T1/2 cells. To initiate transformation, the cells were treated with benzo[a]pyrene [B(a)P; 0.1 µg/mL], and GGN-MRP (0.01, 0.1, and 1.0 mg/mL) was employed to subsequently complete the transformation process. Malignant transformed foci were formed in B(a)P-initiated and GGN-MRPpromoted C3H10T1/2 cells after 8 weeks. Cells treated with GGN-MRP alone failed to induce transformation. However, cells initiated with B(a)P and promoted by GGN-MRP demonstrated oncogenic properties. Transformed colonies derived from GGN-MRP-treated cells exhibited enhanced growth rate, anchorage independence, and tumorgenicity in animals relative to parent cells. These results indicated that GGN-MRP contains a tumor promoter and may induce tumor promotion by two-stage oncogenesis.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/10828 http://dx.doi.org/10.1021/jf0106897
關聯:	J. Agric. Food Chem. 2001, 49, 6063−6067
显示于类别:	[生化微生物免疫研究所] 期刊論文

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