Induction of apoptosis by penta-acetyl geniposide in rat C6 glioma cells.

doi:10.1016/S0009-2797(02)00073-X

中山醫學大學機構典藏 CSMUIR > 醫學院 > 生化微生物免疫研究所 > 期刊論文 > Item 310902500/10821

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题名:	Induction of apoptosis by penta-acetyl geniposide in rat C6 glioma cells.
作者:	Chang, Yun-Ching Tseng, Tsui-Hwa Lee, Miao-Jane Hsu, Jeng-Dong Wang, Chau-Jong
贡献者:	中山醫學大學
关键词:	Penta-acetyl geniposide;C6 glioma cell apoptosis;Cell cycle arrest;p53;c-Myc;Bcl-2;Bax
日期:	2002
上传时间:	2015-05-15T05:36:05Z (UTC)
ISSN:	0009-2797
摘要:	Penta-acetyl geniposide, (Ac)5-GP, was produced by acetylation of a glycoside, isolated from an extract of Gardenia fructus. Previously, we have reported that C6 glioma cells could be inhibited in culturing as well as in bearing rats by treating with (Ac)5-GP. In this study, the effect and action of (Ac)5-GP on inducing cell death was examined in rat C6 glioma cells. Treatment of C6 glioma cells with (Ac)5-GP caused cell death, chromatin condensation, and internucleosomal DNA ladder. Also, cell cycle arrest at G0/G1 phase revealed that (Ac)5-GP-induced cell death appears to be mediated by apoptosis. In addition, the results also showed that p53 and c-Myc increased due to treatment of (Ac)5-GP in a dose–response and time-dependent manner. Concomitant with the expression of p53 and c-Myc, decreased level of Bcl-2 and increased level of Bax protein were observed. These results suggest that cell death caused by (Ac)5-GP through apoptosis and cell cycle arrest at G0/G1 may be associated with the induction of p53, c-Myc and may be mediated with apoptosis-related Bcl-2 family proteins.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/10821 http://dx.doi.org/10.1016/S0009-2797(02)00073-X
關聯:	Chemico-Biological Interactions Volume 141, Issue 3, 20 October 2002, Pages 243–257
显示于类别:	[生化微生物免疫研究所] 期刊論文

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