Hibiscus sabdariffa L. extracts reduce serum uric acid levels in oxonate-induced rats

doi:10.1016/j.jff.2012.01.007

中山醫學大學機構典藏 CSMUIR > 醫學院 > 生化微生物免疫研究所 > 期刊論文 > Item 310902500/10720

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/10720

Title:	Hibiscus sabdariffa L. extracts reduce serum uric acid levels in oxonate-induced rats
Authors:	Kuo, Chih-Yi Kao, Erl-Shyh Chan, Kuei-Chuan Lee, Huei-Jane Huang, Tsai-Feng Wang, Chau-Jong
Contributors:	中山醫學大學
Keywords:	Hyperuricemia;Hibiscus sabdariffa extract;Oxonic acid;Uricase;Xanthine oxidase
Date:	2012
Issue Date:	2015-05-04T10:16:21Z (UTC)
ISSN:	1756-4646
Abstract:	Elevated serum levels of uric acid are associated with an increased risk for hyperuricemia, gout, hypertension, cardiovascular disease, and renal failure. Recent attention has focused on the bioactive properties of edible plants in preventing disease. Hibiscus sabdariffa L., a local soft drink material and medicinal herb in Taiwan, is used effectively in native medicines against hypertension, pyrexia, and liver disorders. We investigated the effects of the Hibiscus sabdariffa extract (HSE) on oxonic acid (OA)-induced hyperuricemia in rats. The HSE affected serum uric acid levels and urate enzymes such as uricase and xanthine oxidase (XO). We treated rats intraperitoneally with normal saline and oxonate solution for 1 week and with or without feeding allopurinol (an XO inhibitor) or HSE (1%, 2%, and 5%) for 5 weeks. We observed that treatment with HSE inhibited OA-induced hyperuricemia, with a greater uric acid lowering effect than allopurinol treatment. Our results showed that HSE effectively inhibited OA-induced hyperuricemia by decreasing uric acid and increasing uricase activity, but not by affecting XO activity.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/10720 http://dx.doi.org/10.1016/j.jff.2012.01.007
Relation:	Journal of Functional Foods Volume 4, Issue 1, January 2012, Pages 375–381
Appears in Collections:	[生化微生物免疫研究所] 期刊論文

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