Mulberry water extracts (MWEs) ameliorated carbon tetrachloride-induced liver damages in rat.

doi:10.1016/j.fct.2012.05.055

中山醫學大學機構典藏 CSMUIR > 醫學院 > 生化微生物免疫研究所 > 期刊論文 > Item 310902500/10717

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/10717

Title:	Mulberry water extracts (MWEs) ameliorated carbon tetrachloride-induced liver damages in rat.
Authors:	Hsu, LS Ho, HH Lin, MC Chyau, CC Peng, JS Wang, CJ
Contributors:	中山醫學大學
Keywords:	Antioxidation, Mulberry water extracts (MWEs);Liver fibrosis, Protection
Date:	2012
Issue Date:	2015-05-04T10:08:18Z (UTC)
ISSN:	0278-6915
Abstract:	Mulberry extracts are antidiabetic and antihyperlipidemic, as well as preventive of cardiovascular disease. The current study investigates the protective mechanisms of mulberry water extracts (MWEs) in carbon tetrachloride (CCl(4))-induced hepatic injury. Oral administration of MWEs significantly reduced the lipid peroxidation triggered by CCl(4), as shown by the reduced production of thiobarituric acid-reactive substance (TBARS). The levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) were also reduced via cotreatment with MWEs compared with CCl(4) treatment alone. Cotreatment with MWE evidently reduced CCl(4)-induced liver weight and inhibited lipid deposition and fibrogenesis. In a similar manner, cotreatment with silymarin, a well-known liver protective agent, also reversed the CCl(4)-induced effects, such as reduced TBARS formation, decreased serum AST, ALT, and ALP levels, blocked lipid accumulation, and liver fibrosis. Furthermore, MWEs attenuated the proinflammatory genes such as cyclooxygenase 2, nuclear factor kappa B, and inducible nitric oxide synthase expression. The current findings suggest that MWEs such as silymarin exhibit protective and curative effects against CCl(4)-induced liver damage and fibrosis via decreased lipid peroxidation and inhibited proinflammatory gene expression. Copyright © 2012 Elsevier Ltd. All rights reserved.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/10717 http://dx.doi.org/10.1016/j.fct.2012.05.055
Relation:	Food Chem Toxicol. 2012 Sep;50(9):3086-93.
Appears in Collections:	[生化微生物免疫研究所] 期刊論文

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