Oat attenuate non-alcoholic fatty liver and obesity via inhibiting lipogenesis in high fat-fed rat

doi:10.1016/j.jff.2012.08.003

中山醫學大學機構典藏 CSMUIR > 醫學院 > 生化微生物免疫研究所 > 期刊論文 > Item 310902500/10716

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/10716

Title:	Oat attenuate non-alcoholic fatty liver and obesity via inhibiting lipogenesis in high fat-fed rat
Authors:	Peng, Chiung-Huei Chang, Hong-Chou Yang, Mon-Yuan Huang, Chien-Ning Wang, Shing-Jung Wang, Chau-Jong
Contributors:	中山醫學大學
Keywords:	Oat;Obesity;Body fat;Liver lipid
Date:	2013
Issue Date:	2015-05-04T10:04:42Z (UTC)
ISSN:	1756-4646
Abstract:	Obesity accompanied with metabolic disorder is often complicated by hepatic regulations of lipid metabolism and lipoprotein recruitment. Recent reports have suggested that oat has metabolic-regulating effect. In this study, we examined whether oat could improve obesity, body fat, serum parameters and liver lipid metabolism. In high-fat-diet (HFD)-fed rats, oat effectively reduced body weight and fat, and decreased food efficiency but not appetite. Oat lowered serum glucose, free-fatty-acid (FFA), triacylglycerol (TG), cholesterol, and LDL-C/HDL-C elevated by HFD, and dose-dependently reduced hepatic TG and cholesterol. Thirty percent oat markedly reduced lipid synthesis biomarkers FAS, GPAT and HMG CoA reductase, while 15% and 30% oat stimulated expressions of oxidation markers PPARα, CPT-1 and phosphorylated-AMPK. Oat increased LDL receptor, being beneficial for serum lipid-lowering. Thus, Oat could act as adjuvant therapeutics for metabolic disorders via attenuating obesity, body fat, and improving serum parameters with metabolic regulation and lipid clearance of liver. Oat attenuate non-alcoholic fatty liver and obesity via inhibiting lipogenesis in high fat-fed rat - ResearchGate. Available from: http://www.researchgate.net/publication/257694737_Oat_attenuate_non-alcoholic_fatty_liver_and_obesity_via_inhibiting_lipogenesis_in_high_fat-fed_rat [accessed May 4, 2015].
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/10716 http://dx.doi.org/10.1016/j.jff.2012.08.003
Relation:	Journal of Functional Foods (Impact Factor: 4.48). 01/2013; 5(1):53–61.
Appears in Collections:	[生化微生物免疫研究所] 期刊論文

Files in This Item:

File	Description	Size	Format
index.html	期刊論文	0Kb	HTML	355	View/Open

View Licence

Loading...