Mulberry leaf polyphenol extracts reduced hepatic lipid accumulation involving regulation of adenosine monophosphate activated protein kinase and lipogenic enzymes

doi:10.1016/j.jff.2013.07.004

中山醫學大學機構典藏 CSMUIR > 醫學院 > 生化微生物免疫研究所 > 期刊論文 > Item 310902500/10708

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题名:	Mulberry leaf polyphenol extracts reduced hepatic lipid accumulation involving regulation of adenosine monophosphate activated protein kinase and lipogenic enzymes
作者:	Wu, Cheng-Hsun Chen, Shu-Chun Ou, Ting-Tsz Chyau, Charng-Cherng Changd, Yun-Ching Wang, Chau-Jong
贡献者:	中山醫學大學
关键词:	Mulberry leaf polyphenol extracts;Fatty acid synthetase;Acetyl-CoA carboxylase;HMG-CoA reductase;AMP-actived protein kinase;Non-alcoholic fatty liver disease
日期:	2013
上传时间:	2015-05-01T04:51:07Z (UTC)
ISSN:	1756-4646
摘要:	Fat accumulation in the liver increases the risk of developing progressive liver injury. It can induce all the symptoms of metabolic syndrome, which is associated with many additional health problems, including increased risk of obesity, hypertension, insulin resistance, and non-alcoholic fatty liver disease (NAFLD). Therefore, prevention and treatment of fat accumulation in the liver are relevant to health promotion. Mulberry leaf polyphenol extracts (MLPE) have been known to modulate serum fasting glucose, lipid and antiatherosclerosis. However, the effect of MLPE on regulating hepatic lipid metabolism is unclear. This study evaluated the effects and mechanisms of MLPE in reducing hepatic lipid accumulation in cell culture. We found MLPE could regulate hepatic lipid accumulation. Further, numerous lipogenic enzymes, such as FAS (fatty acid synthetase), ACC (acetyl-CoA carboxylase), HMGCR (HMG-CoA reductase) and associated-lipogenic transcriptional factors (SREBP1 and SREBP2) were suppressed by MLPE. Our results show MLPE is able to reduce hepatic lipid accumulation through activation of the AMPK (AMP-activating protein kinase) signaling pathway. It may have potential therapeutic implications for human NFALD.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/10708 http://dx.doi.org/10.1016/j.jff.2013.07.004
關聯:	Journal of Functional Foods Volume 5, Issue 4, October 2013, Pages 1620–1632
显示于类别:	[生化微生物免疫研究所] 期刊論文

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