Mulberry leaf polyphenol extracts reduced hepatic lipid accumulation involving regulation of adenosine monophosphate activated protein kinase and lipogenic enzymes

doi:10.1016/j.jff.2013.07.004

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Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/10708

Title:	Mulberry leaf polyphenol extracts reduced hepatic lipid accumulation involving regulation of adenosine monophosphate activated protein kinase and lipogenic enzymes
Authors:	Wu, Cheng-Hsun Chen, Shu-Chun Ou, Ting-Tsz Chyau, Charng-Cherng Changd, Yun-Ching Wang, Chau-Jong
Contributors:	中山醫學大學
Keywords:	Mulberry leaf polyphenol extracts;Fatty acid synthetase;Acetyl-CoA carboxylase;HMG-CoA reductase;AMP-actived protein kinase;Non-alcoholic fatty liver disease
Date:	2013
Issue Date:	2015-05-01T04:51:07Z (UTC)
ISSN:	1756-4646
Abstract:	Fat accumulation in the liver increases the risk of developing progressive liver injury. It can induce all the symptoms of metabolic syndrome, which is associated with many additional health problems, including increased risk of obesity, hypertension, insulin resistance, and non-alcoholic fatty liver disease (NAFLD). Therefore, prevention and treatment of fat accumulation in the liver are relevant to health promotion. Mulberry leaf polyphenol extracts (MLPE) have been known to modulate serum fasting glucose, lipid and antiatherosclerosis. However, the effect of MLPE on regulating hepatic lipid metabolism is unclear. This study evaluated the effects and mechanisms of MLPE in reducing hepatic lipid accumulation in cell culture. We found MLPE could regulate hepatic lipid accumulation. Further, numerous lipogenic enzymes, such as FAS (fatty acid synthetase), ACC (acetyl-CoA carboxylase), HMGCR (HMG-CoA reductase) and associated-lipogenic transcriptional factors (SREBP1 and SREBP2) were suppressed by MLPE. Our results show MLPE is able to reduce hepatic lipid accumulation through activation of the AMPK (AMP-activating protein kinase) signaling pathway. It may have potential therapeutic implications for human NFALD.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/10708 http://dx.doi.org/10.1016/j.jff.2013.07.004
Relation:	Journal of Functional Foods Volume 5, Issue 4, October 2013, Pages 1620–1632
Appears in Collections:	[The Institute of Biochemistry, Microbiology and Immunology ] Journal Paper

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