Efficacy of curcumin therapy against Angiostrongylus cantonensis-induced eosinophilic meningitis.

doi:10.1017/S0022149X07182353

中山醫學大學機構典藏 CSMUIR > 醫學院 > 醫學系 > 期刊論文 > Item 310902500/10665

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://ir.csmu.edu.tw:8080/ir/handle/310902500/10665

题名:	Efficacy of curcumin therapy against Angiostrongylus cantonensis-induced eosinophilic meningitis.
作者:	Shih, PC Lee, HH Lai, SC Chen, KM Jiang, ST Shiow, SJ Chen, YF
贡献者:	中山醫學大學
日期:	2007
上传时间:	2015-04-20T09:10:14Z (UTC)
ISSN:	0022-149X
摘要:	Angiostrongylus cantonensis can invade the central nervous system, leading to human eosinophilic meningitis or eosinophilic meningoencephalitis. Curcumin is a natural product which has the effects of anti-inflammation, anti-oxidation and anti-carcinogensis, while the administration of curcumin has been reported to possibly relieve the symptoms of meningitis. The present study tested the potential efficacy of curcumin in A. cantonensis-induced eosinophilic meningitis of BALB/c mice. Assay indicators for the therapeutic effect included the larvicidal effect, eosinophil counts and matrix metalloproteinase-9 (MMP-9) activity in angiostrongyliasis. Eosinophils were mildly reduced in treatment groups compared with infected-untreated mice. However, there were no significant differences in larvicidal effects or MMP-9 activity. This study suggests that anti-inflammatory treatment with curcumin alone has low efficacy, but the treatment does not interfere with MMP-9 expression and is not useful for larvicidal effects. The possible reasons include low curcumin across the blood-brain barrier and also those larvae that survive stimulate MMP-9 production, which promotes blood-brain barrier damage, with leukocytes then crossing the blood-brain barrier to cause meningitis. Further studies will be required to test these possibilities.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/10665 http://dx.doi.org/10.1017/S0022149X07182353
關聯:	J Helminthol. 2007 Mar;81(1):1-5.
显示于类别:	[醫學系] 期刊論文

文件中的档案:

档案	描述	大小	格式	浏览次数
index.html	期刊論文	0Kb	HTML	606	检视/开启

检视Licence

在CSMUIR中所有的数据项都受到原著作权保护.

TAIR相关文章

数据加载中.....