Cytotoxicity and arecoline mechanisms in human gingival fibroblasts in vitro.

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 牙醫學系暨碩士班 > 期刊論文 > Item 310902500/10642

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题名:	Cytotoxicity and arecoline mechanisms in human gingival fibroblasts in vitro.
作者:	Chang, YC Hu, CC Lii, CK Tai, KW Yang, SH Chou, MY
贡献者:	中山醫學大學
日期:	2001
上传时间:	2015-04-13T09:24:59Z (UTC)
摘要:	Betel nut chewing, like cigarette smoking, is a popular oral habit which impinges on the daily lives of a population of approximately 200 million. People who chew betel nuts have a higher prevalence of periodontal diseases than those who do not. Many of the undesirable effects of betel nuts have been attributed to arecoline, a major component of the particular alkaloid in betel nuts. In this in vitro study, we have focused on the effects of arecoline and the role it could play in periodontal breakdown via its direct effects on human gingival fibroblasts. Human gingival fibroblasts were derived from three healthy individuals undergoing crown-lengthening procedures. We found that arecoline is cytotoxic to human gingival fibroblasts at a concentration higher than 50 micrograms/ml by depleting intracellular thiols and inhibiting mitochondrial activity (P < 0.05). In addition, the cells displayed a marked arrest at G2/M phase in a dose-dependent manner. Repeated and long-term exposure to arecoline could impair the gingival fibroblast functions. As they are cytotoxic, the use of betel nut products in conjunction with periodontal therapy may interfere with optimal healing and/or lead to further periodontal breakdown.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/10642
關聯:	Clin Oral Investig. 2001 Mar;5(1):51-6.
显示于类别:	[牙醫學系暨碩士班] 期刊論文

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