Cytotoxic and non-genotoxic effects of arecoline on human buccal fibroblasts in vitro.

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 牙醫學系暨碩士班 > 期刊論文 > Item 310902500/10629

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题名:	Cytotoxic and non-genotoxic effects of arecoline on human buccal fibroblasts in vitro.
作者:	Chang, YC Tai, KW Cheng, MH Chou, LS Chou, MY
贡献者:	中山醫學大學
日期:	1998
上传时间:	2015-04-10T08:33:18Z (UTC)
摘要:	Betel quid chewing has been linked to oral submucous fibrosis and oral cancer. Cytotoxicity and genotoxicity assays were used to investigate the pathobiological effects of arecoline on cultured human buccal fibroblasts. Arecoline increased double-stranded polynucleic acid at the concentration of 0.1 to 10 micrograms/ml in a concentration-dependent manner. At a concentration higher than 50 micrograms/ml, arecoline was cytotoxic to cultured fibroblasts and the cytotoxicity was dose-dependent. No genotoxicity for arecoline was found even at a concentration of 400 micrograms/ml. On the other hand, 600 micrograms/ml glutathione (GSH) and 200 micrograms/ml glycyrrhizin could prevent the arecoline-induced cytotoxicity. These results indicate that arecoline is a cytotoxic agent and no genotoxicity was found to human buccal fibroblasts. Furthermore, increasing consumption of GSH- and glycyrrhizin-rich foods may reduce the oral diseases associated with betel quid chewing.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/10629
關聯:	J Oral Pathol Med. 1998 Feb;27(2):68-71.
显示于类别:	[牙醫學系暨碩士班] 期刊論文

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