Mechanism of Pingyangmycin in Inhibition of KB Cell Activity

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 牙醫學系暨碩士班 > 期刊論文 > Item 310902500/10627

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题名:	Mechanism of Pingyangmycin in Inhibition of KB Cell Activity
作者:	戴國維張育超周林世珍周明勇
贡献者:	中山醫學大學
日期:	1997
上传时间:	2015-04-10T08:29:51Z (UTC)
摘要:	The antitumor antibiotic pingyangmycin (PYM; bleomycin A�N) is produced by Streptomyces pingyangensisn. The chemical structure or PYM is similar to that of bleomycin (BLM), but their terminal amine moieties are different, and the mechanism of PYM inhibition of tumor growth has not been well studied. In this article, we used the multiwell / cell growth curve method to assess the inhibition KB cell growth by PYM; we also investigated the mechanism of tumor cell growth as well as the morphological variations of drug-treated cells. DNA synthesis inhibition assay was used to evaluate the antitumor mechanism of PYM. Treatment with 5 μ g/ml PYM for 24 hours significantly inhibited cell growth and synthesis of DNA (p<0.05). Therefore, it appears PYM exerts its inhibitory effect on KB cell growth by inhibiting synthesis of DNA.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/10627
關聯:	中華牙醫學雜誌 16:4 民86.12 頁210-217
显示于类别:	[牙醫學系暨碩士班] 期刊論文

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