Expression of carbonic anhydrases I/II and the correlation to clinical aspects of oral squamous cell carcinoma analyzed using tissue microarray.

doi:10.1111/j.1600-0714.2012.01135.x

中山醫學大學機構典藏 CSMUIR > 口腔醫學院 > 牙醫學系暨碩士班 > 期刊論文 > Item 310902500/10567

Please use this identifier to cite or link to this item: https://ir.csmu.edu.tw:8080/ir/handle/310902500/10567

Title:	Expression of carbonic anhydrases I/II and the correlation to clinical aspects of oral squamous cell carcinoma analyzed using tissue microarray.
Authors:	Liu, CM Lin, YM Yeh, KT Chen, MK Chang, JH Chen, CJ Chou, MY Yang, SF Chien, MH
Contributors:	中山醫學大學
Date:	2012
Issue Date:	2015-03-30T10:13:32Z (UTC)
ISSN:	0904-2512
Abstract:	Abstract BACKGROUND: Carbonic anhydrases (CA), a family of metalloenzymes, play an important role in catalyzing the equilibration of carbon dioxide (CO(2)) and carbonic acid (H(2)CO(3)). The role of CAs in tumorigenesis is controversial, especially regarding the expression of CA isoenzymes between various tumor types. This study explores the correlation between the expressions of CA I and CA II and the characteristic features of oral cancer. METHODS: We immunohistochemically examined the expressions of CA I and CA II in 279 cases of oral squamous cell carcinoma (OSCC) using tissue microarrays. Additionally, the oral cancer cell line SCC-9 was used to confirm the relationship between CA I and CA II expression and cell growth. RESULTS: We found a significant correlation between positive CA I and CA II stains and OSCC for more advanced clinical stage (P = 0.014 or 0.012) and larger tumor size (P = 0.008 or 0.038), but not for positive lymph node metastasis, distal metastasis, and recurrence. In vitro analysis also showed that treatment with a CA inhibitor, acetazolamide, inhibited the growth of SCC-9 cells. CONCLUSION: We conclude that expressions of CA I and CA II in OSCC samples can be used to predict local tumor growth in OSCC patients. © 2012 John Wiley & Sons A/S.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/10567 http://dx.doi.org/10.1111/j.1600-0714.2012.01135.x
Relation:	J Oral Pathol Med. 2012 Aug;41(7):533-9.
Appears in Collections:	[牙醫學系暨碩士班] 期刊論文

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