中山醫學大學機構典藏 CSMUIR:Item 310902500/10533
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    题名: Clinical correlation with the PA/plasmin system in septic arthritis of the knee.
    作者: Hsieh YS
    Yang SF
    Lue KH
    Lu KH
    贡献者: 中山醫學大學
    日期: 2006-06
    上传时间: 2015-03-23T03:59:02Z (UTC)
    ISSN: 0009-921X
    摘要: Substantially more gelatinases appear in effusions of septic arthritis than in effusions of aseptic arthritis. We hypothesized there is greater plasminogen activator/plasmin activity in effusions of septic arthritis than aseptic arthritis. We examined the antigenic values of urokinase-type plasminogen activator and plasminogen activator inhibitor Type-1, cell counts, and levels of matrix metalloproteinase-2 and metalloproteinase-9 in 135 knee effusions from 80 patients with septic arthritis, rheumatoid arthritis, gouty arthritis, and osteoarthritis. Urokinase-type plasminogen activator and plasminogen activator inhibitor Type-1 antigenic values in effusions of septic arthritis were greater than those in effusions of aseptic arthritis. The increases of urokinase-type plasminogen activator and plasminogen activator inhibitor Type-1 antigenic values in effusions were associated with increased levels of prometalloproteinase-9 and the appearance of activated metalloproteinase-2. Antigenic values of urokinase-type plasminogen activator also correlated with the appearance of activated metalloproteinase-9. High plasminogen activator/plasmin activity, prometalloproteinase-9 levels, and the presence of activated metalloproteinase-2 and metalloproteinase-9 in effusions from replaced knees should increase suspicion of infection regardless of neutrophil counts. Joint aspiration reduces bacteria counts, endotoxins, proinflammatory cytokines, and matrix metalloproteinase. It also decreases the plasminogen activator/plasmin activity in effusions that may play a part in extracellular matrix destruction.
    URI: https://ir.csmu.edu.tw:8080/ir/handle/310902500/10533
    http://dx.doi.org/10.1097/01.blo.0000203473.96549.4e
    關聯: Clin Orthop Relat Res. 2006 Jun;447:172-8.
    显示于类别:[醫學系] 期刊論文

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