Association of a lymphotoxin-alpha gene polymorphism and atopic asthma in Taiwanese children.

doi:10.1016/S1875-9572(08)60008-X

中山醫學大學機構典藏 CSMUIR > 醫學院 > 醫學系 > 期刊論文 > Item 310902500/10496

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题名:	Association of a lymphotoxin-alpha gene polymorphism and atopic asthma in Taiwanese children.
作者:	Huang SC Wu WJ Sun HL Lue KH Hsu CH Liao PF Ku MS
贡献者:	中山醫學大學
关键词:	atopic asthma;gene polymorphism;lymphotoxin-α gene
日期:	2008-04
上传时间:	2015-03-18T04:48:57Z (UTC)
ISSN:	1875-9572
摘要:	BACKGROUND: The lymphotoxin-alpha (LT-alpha) gene is located on chromosome 6 (6p21.1-6p21.3) and it may regulate tumor necrosis factor (TNF) production. TNF is a potent cytokine in the airway inflammatory response. Polymorphisms of TNF-associated genes have been related to asthma. This study investigated an LT-alpha-Ncol polymorphism in the first intron of the LT-alpha gene (LT-alpha-Ncol1 allele, as a variant type; and LT-alpha-Ncol2 allele), which may predispose individuals to asthma and atopy. METHODS: Polymerase chain reaction-based assays were performed to determine LT-alpha-Ncol genotypes among our subjects. A genetic case control analysis was then performed on 114 atopic asthmatic and 155 non-asthmatic unrelated children. RESULTS: There was a statistically higher frequency of LT-alpha-Ncol1 allele carriers (1/1+1/2) in the subjects with atopic asthma than in controls (OR=1.923; 95% CI = 1.061-3.484; p = 0.031). CONCLUSION: The results indicate that LT-alpha-Ncol1 may be a risk factor for atopic asthma in Taiwanese children.
URI:	https://ir.csmu.edu.tw:8080/ir/handle/310902500/10496 http://dx.doi.org/10.1016/S1875-9572(08)60008-X
显示于类别:	[醫學系] 期刊論文

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